The Role of Whole Body DWI in the Evaluation of Bone Disease in Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2022.02.029
- Author:
Yan XIE
1
;
You-You HUI
2
;
Fei-Rong YAO
3
;
Chun-Hong HU
3
;
Ling-Zhi YAN
1
;
De-Pei WU
1
;
Cheng-Cheng FU
4
Author Information
1. The First Affiliated Hospital of Soochow University, National Clinical Research Center for Hematologic Diseases(Suzhou), Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215000, Jiangsu Province, China.
2. Wuxi Woman and Enfants Care Hospital, Wuxi 214002, Jiangsu Province, China.
3. The First Affiliated Hospital of Soochow University, Institute of Imaging Medicine, Soochow University, Suzhou 215000, Jiangsu Province, China.
4. The First Affiliated Hospital of Soochow University, National Clinical Research Center for Hematologic Diseases(Suzhou), Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215000, Jiangsu Province, China,E-mail: fuchengchengsz@163.com.
- Publication Type:Journal Article
- Keywords:
R-ISS stage;
apparent diffusion coefficient;
multiple myeloma;
whole body diffusion weighted imaging
- MeSH:
Bone Diseases;
Diffusion Magnetic Resonance Imaging;
Humans;
Multiple Myeloma/diagnostic imaging*;
Retrospective Studies;
Whole Body Imaging
- From:
Journal of Experimental Hematology
2022;30(2):501-505
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the characteristics of ADC value changes in DWI of newly diagnosed symptomatic MM patients and its correlation with R-ISS stage.
METHODS:The data of 148 newly diagnosed symptomatic MM patients treated by whole-body DWI scan at The First Affiliated Hospital of Soochow University from June 2016 to June 2019 were selected and retrospectively analyzed and 30 cases of age-matched healthy people were selected as controls. The differences of ADC values between the patients in normal control group, DWI- group and DWI+ group were compared, and the relationship between ADC values and R-ISS stage in MM patients was compared.
RESULTS:The plasma cell percentage of the patients in DWI+ group was higher than those in DWI- group. ADC values of vertebra, sternum, rib, pectoral girdle, pelvic girdle of the patients in DWI+ group were significantly higher than those in DWI- group and normal control group. The ADC values of each part of the patients in DWI- group were higher than those in normal control group. ADC values of sternum, rib and pectoral girdle in the patients at R-ISS stage III were higher than those at R-ISS stage I and II, while, there was no statistical difference between R-ISS stage I and II groups. And there was no significant difference in ADC values of other bone parts such as vertebra and pelvic girdle in patients at R-ISS stage Ⅰ-Ⅲ.
CONCLUSION:DWI+ in MM patients is related to higher tumor invasion. The ADC values of the DWI+ group are higher than those of the DWI- group; the bone ADC values of the DWI- patients are still higher than the normal ones. And there is a certain relationship between ADC value and R-ISS stage.
