Research Progress on the Mechanism of Tubulin in Megakaryopoiesis and Regulation of Platelet Count--Review.
10.19746/j.cnki.issn.1009-2137.2022.01.054
- Author:
Si-Ying NIU
1
;
Li-Jun XIA
2
;
Miao JIANG
3
Author Information
1. National Clinical Medical Research Center of Blood Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215007, China,Key Laboratory of Thrombosis & Hemostasis of National Health Commission of People's Republic of China, Suzhou 215006, China.
2. National Clinical Medical Research Center of Blood Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215007, China,Key Laboratory of Thrombosis & Hemostasis of National Health Commission of People's Republic of China, Suzhou 215006, China,E-mail: ljxia@suda.edu.cn.
3. National Clinical Medical Research Center of Blood Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215007, China,Key Laboratory of Thrombosis & Hemostasis of National Health Commission of People's Republic of China, Suzhou 215006, China,E-mail: jiangmiao@suda.edu.cn.
- Publication Type:Review
- Keywords:
TUBB1;
megakaryocyte;
thrombocytopenia;
thrombopoiesis;
tubulin
- MeSH:
Blood Platelets;
Humans;
Megakaryocytes;
Platelet Count;
Thrombopoiesis;
Tubulin
- From:
Journal of Experimental Hematology
2022;30(1):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Tubulin affects platelets count through the control of mitosis and the formation of pro-platelets during the maturation of megakaryoblast to platelets. Tubulin is involved in maintaining the integrity of platelet skeleton, and also participates in the change of platelet morphology during platelet activation. Some new anti-tumor drugs targeting cell mitosis are trying to reduce the effect on tubulin in order to reduce the side effect of drugs on platelet formation. In some patients with thrombocytopenia, the variation and polymorphism of the tubulin gene affect the structure of microtubule multimers, which leads to the decrease of platelet formation. This review summarized the latest progresses of tubulin in the regulation of megakaryopoiesis and thrombopoiesis.
