Research Progress of Intercellular Mitochondrial Transfer in the Development of Hematological Malignant Tumors --Review.
10.19746/j.cnki.issn.1009-2137.2022.01.051
- Author:
Liu-Yun ZHANG
1
;
Yun-Hui XIANG
1
;
Juan ZHANG
2
Author Information
1. School of Medicine University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China.
2. Department of Clinical Medical Laboratory Center, The Affiliated Hospital of University of Electronic Science and Technology of China ＆ Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China,E-mail: zhangjuan82@126.com.
- Publication Type:Review
- Keywords:
mitochondrial transfer;
bone marrow mesenchymal stem cells;
hematological malignant tumor;
tunneling nanotubes
- MeSH:
Bone Marrow;
Hematologic Neoplasms/metabolism*;
Humans;
Mesenchymal Stem Cells;
Mitochondria;
Multiple Myeloma/metabolism*;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2022;30(1):310-313
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, studies have found that mitochondrial transfer between leukemic cells and different types of cells in their bone marrow microenvironment, especially mesenchymal stem cells, plays a key role in the occurrence, development and drug resistance of hematological malignant tumors. This paper mainly introduces the role and latest research progress of mitochondrial transfer in acute and chronic myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma, and briefly describes the mechanism of drug resistance caused by mitochondrial transfer in leukemic cells during chemotherapy. The aim is to provide a new idea and theoretical basis for using intercellular mitochondrial transfer as a potential therapeutic target.
