Correlation between Serum Homocysteine Level, MTHFR Gene Polymorphism and Patients with Hematological Diseases Complicated with Coronary Heart Disease.
10.19746/j.cnki.issn.1009-2137.2022.01.050
- Author:
Ling ZHANG
1
;
Xiao-Fei YUAN
1
;
Qi LI
1
;
Ling FAN
1
;
Zhe CHEN
1
;
Bin ZHANG
2
;
Bing-Hua GAO
3
Author Information
1. Department of Hematology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China.
2. Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China.
3. Department of Hematology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China,E-mail: gbhxyk@126.com.
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
correlation;
hematological disease;
methylenetetrahydrofolate reductase gene polymorphism;
serum homocysteine
- MeSH:
Coronary Disease/genetics*;
Genotype;
Hematologic Diseases/complications*;
Homocysteine;
Humans;
Methylenetetrahydrofolate Reductase (NADPH2)/genetics*;
Polymorphism, Genetic
- From:
Journal of Experimental Hematology
2022;30(1):305-309
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression level of serum homocysteine (Hcy) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in patients with hematological diseases complicated with coronary heart disease, and analyze the relationship between serum Hcy level, MTHFR gene polymorphism and coronary heart disease.
METHODS:The medical records of 80 patients with coronary heart disease who completed treatment of hematological diseases during the period from March 2018 to March 2020 were selected as observation group. In addition, the medical records of 92 patients with hematological diseases who completed treatment in our hospital during the same period were selected as control group. Venous blood samples of the two groups were collected to detect serum Hcy level and MTHFR gene polymorphism. The serum Hcy levels of the two groups with different MTHFR genotypes were compared, and the effects of the above indicators on hematological diseases complicated with coronary heart disease were analyzed.
RESULTS:The detection rates of MTHFR gene TT and TC in the observation group were higher than those in the control group, while the distribution frequency of MTHFR genotype CC was lower (P<0.05). The serum Hcy levels of the patients with MTHFR genotype TT and TC in the observation group was higher than the control group (P<0.05). Binary logistic regression analysis showed that MTHFR gene TC/CC genotype serum Hcy overexpression may be influencing factor which induced coronary heart disease in patients with hematological diseases (OR=2.107/OR=1.634, P<0.05). ROC curves showed that the AUC of serum Hcy level of MTHFR gene TC/CC genotype and hematological disease complicated with coronary heart disease were both > 0.8. When MTHFR gene TC reaching the optimal threshold of 22.165 μmol/L, the sensitivity was 0.950 and the specificity was 0.837, While MTHFR gene CC reached the optimal threshold of 19.630 μmol/L, the sensitivity was 0.938 and the specificity was 0.826, the best predictive value could be obtained.
CONCLUSION:The changes of serum Hcy and MTHFR gene polymorphisms may be involved in the pathological process in patients with hematological diseases complicated with coronary heart disease. In the future, early detection of serum Hcy levels and MTHFR gene polymorphisms in patients with hematological diseases can be used to predict the risk of coronary heart disease.
