Value of 18F-FDG PET/CT Imaging in Secondary Extramedullary Infiltration of Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2022.01.031
- Author:
Bo PAN
1
;
Shi-Cun WANG
2
;
Feng-Lin ZHAN
2
;
Ming NI
2
;
Xin LIU
2
;
Yi-Fan ZHANG
2
;
Qiang XIE
2
;
Ji-Kui XIE
2
Author Information
1. Department of Nuclear Medicine, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui Province, China,E-mail: panbows@163.com.
2. Department of Nuclear Medicine, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui Province, China.
- Publication Type:Journal Article
- Keywords:
extra-medullary involvement;
multiple myeloma;
positron emission tomography/computed tomography;
standardized uptake value
- MeSH:
Adult;
Aged;
Female;
Fluorodeoxyglucose F18;
Humans;
Male;
Middle Aged;
Multiple Myeloma/diagnostic imaging*;
Positron Emission Tomography Computed Tomography;
Positron-Emission Tomography;
Retrospective Studies
- From:
Journal of Experimental Hematology
2022;30(1):189-194
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the characteristics of 18F-FDG PET/CT images of multiple myeloma secondary extramedullary infiltration in order to improve recognition.
METHODS:Twenty-one patients with multiple myeloma secondary extramedullary infiltration confirmed by pathology or follow-up from January 2012 to October 2020 in the First Affiliated Hospital of University of Science and Technology of China were retrospectively analyzed. All the patients underwent 18F-FDG PET/CT imaging before treatment, and the PET/CT characteristics of extramedullary infiltration and bone marrow were analyzed.
RESULTS:Twenty-one patients included 12 males and 9 females, aged from 41 to 77 years old, with an average of 58.3±10.0; 9 cases of extramedullary infiltration involving lymph nodes; lung, stomach, spleen, and kidney were involved respectively in 2 cases; retroperitoneal, right auricle, subcutaneous nodule, and spinal meninges involvement were reported in each one case respectively. The maximum SUVmax value of extra-medullary lesions was 21.2, the minimum value was 2.1, and mean was 7.7±5.3. The maximum SUVmax value of bone marrow was 33.5, the minimum was 2.4, and mean was 6.6±3.6. There was no statistically significant difference in SUVmax value between extra-medullary lesions and bone marrow (Z=-1.195, P=0.232).
CONCLUSION:18F-FDG PET/CT not only has a good diagnostic value for multiple myeloma, but also a good evaluation value for secondary extramedullary infiltration, which provides reference for clinical treatment and prognosis.
