Clinical Analysis of Acute Myeloid Leukemia Patients with Hemophagocytic Syndrome.
10.19746/j.cnki.issn.1009-2137.2022.01.015
- Author:
Ya-Ping WANG
1
;
Shi-Xin WU
1
;
Xue-Ya ZHANG
2
Author Information
1. Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
2. Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China,E-mail: jakey3456@sina.com.
- Publication Type:Journal Article
- Keywords:
acute myeloid leukemia;
clinical characteristic;
hemophagocytic syndrome;
prognosis
- MeSH:
Aged;
Antineoplastic Combined Chemotherapy Protocols;
Bone Marrow;
Female;
Humans;
Leukemia, Myeloid, Acute/drug therapy*;
Lymphohistiocytosis, Hemophagocytic/complications*;
Male;
Prognosis;
Treatment Outcome
- From:
Journal of Experimental Hematology
2022;30(1):92-98
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features of acute myeloid leukemia patients with hemophagocytic syndrome.
METHODS:The clinical data of 2 patients with acute myeloid leukemia complicated with hemophagocytic syndrome were collected, and the clinical characteristics and treatment outcomes were analyzed.
RESULTS:There were two patients with acute myeloid leukemia, including 1 male and 1 female，aged for 67 and 40 years old，respectively. Hemophagocytic syndrome occurred in one patient after induction therapy for acute myeloid leukemia and one patient after consolidation therapy. Both of the patients with hemophagocytic syndrome showed fever, hemocytopenia, high ferritin, high titer sCD25 levels and hemophagocytes in bone marrow. After achieved anti-infection, glucocorticoid, human immunoglobulin and etoposide regimens treatment, hemophagocytic syndrome was controlled in both of the two patients. One patient failed to induce acute myeloid leukemia and one patient achieved complete remission.
CONCLUSION:Acute myeloid leukemia complicated with hemophagocytic syndrome is rare. Early identification, early anti-infection combined with HLH94 regimen can control hemophagocytosis and improve prognosis.
