The Genetic and Prognostic Characteristics of AML-MRC Patients.
10.19746/j.cnki.issn.1009-2137.2022.01.004
- Author:
Zhe CHEN
1
;
Qi-Tian MU
2
;
An WU
1
;
Gui-Fang OUYANG
3
Author Information
1. Ningbo University Medical School, Ningbo 315000, Zhejiang Province, China.
2. Ningbo First Hospital, Ningbo 315010, Zhejiang Province, China.
3. Ningbo First Hospital, Ningbo 315010, Zhejiang Province, China,E-mail: nbougf@163.com.
- Publication Type:Journal Article
- Keywords:
5q-;
TP53;
acute myeloid leukemia with myelodysplasia-related changes;
complex karyotype;
overall survival
- MeSH:
Humans;
Karyotype;
Karyotyping;
Leukemia, Myeloid, Acute/genetics*;
Myelodysplastic Syndromes;
Prognosis
- From:
Journal of Experimental Hematology
2022;30(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic and prognostic characteristics of acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) patients.
METHODS:There were 230 non-M3 AML patients treated in Ningbo First Hospital enrolled, among which 58 patients were newly diagnosed AML-MRC, the patients were followed up and SPSS 25.0 was used to statistically analyze.
RESULTS:There were 49 patients performed genetic testing, 29 patients (59.2%) showed chromosomal abnormalities, including 7q- 8 cases (16.3%), 5q- 6 cases (12.2%), 5 cases (10.2%) of 17p abnormalities, 13 cases (26.5%) of highly abnormal complex karyotypes (CK) (≥5 unrelated chromosomal abnormalities), CK contained chromosomal abnormalities such as +8, 5q-, and 12 cases (24.5%) of monosomal karyotypes (MK). Genetic testing was performed in 37 patients, and 24 (64.9%) patients showed genetic mutations, among which ASXL1 mutation was the most common (8 cases, 21.6%), followed by TET2 mutation in 6 cases (16.2%). Kaplan-Meier analysis showed that AML-MRC patients with high CK (P=0.012), 5q- abnormalities (P=0.038), and TP53 mutations (P=0.008) had poor overall survival.
CONCLUSION:AML-MRC has unique genetic characteristics, and high CK, 5q- and TP53 mutations are poor prognostic factors.
