Advances in relationship between cell senescence and atherosclerosis.
10.3724/zdxbyxb-2021-0270
- Author:
Dekun LIU
1
;
Jiali LIU
1
;
Dan ZHANG
2
;
Wenqing YANG
3
Author Information
1. 1. Faculty of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250300, China.
2. 3. Innovation Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250300, China.
3. 2. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250300, China.
- Publication Type:Review
- Keywords:
Atherosclerosis;
Organelles;
Review;
Senescence cells;
Senescence-associated secretory phenotype;
Treatment strategies
- MeSH:
Aging;
Atherosclerosis;
Cardiovascular Diseases;
Cellular Senescence;
Chronic Disease;
Humans;
Senescence-Associated Secretory Phenotype
- From:
Journal of Zhejiang University. Medical sciences
2022;51(1):95-101
- CountryChina
- Language:English
-
Abstract:
Cellular senescence is a biological process associated with the degeneration of cell structure and function, which contribute to age-related diseases. Atherosclerosis is a chronic inflammatory disease that can cause a variety of cardiovascular disorders. In this article, we review the effects of cellular senescence on the development of atherosclerosis through diverse physiopathological changes, focusing on the alterations in senescent organelles and the increased senescence-associated secretory phenotype (SASP), and exploring the relevant therapeutic strategies for atherosclerosis by clearing senescent cells and reducing SASP, to provide new insights for the treatment of atherosclerosis.
