Sex differences in clinical outcomes of extremely preterm infants/extremely low birth weight infants: a propensity score matching study.
10.7499/j.issn.1008-8830.2201049
- Author:
Zhi-Wen SU
1
;
Li-Li LIN
1
;
Bi-Jun SHI
1
;
Xiao-Xia HUANG
1
;
Jian-Wei WEI
1
;
Chun-Hong JIA
1
;
Fan WU
1
;
Qi-Liang CUI
1
Author Information
1. Department of Pediatrics, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
- Publication Type:Journal Article
- Keywords:
Clinical outcome;
Extremely low birth weight infant;
Extremely preterm infant;
Propensity score matching;
Sex
- MeSH:
Bronchopulmonary Dysplasia/etiology*;
Female;
Humans;
Infant;
Infant, Extremely Low Birth Weight;
Infant, Extremely Premature;
Infant, Newborn;
Male;
Pregnancy;
Propensity Score;
Retrospective Studies;
Sex Characteristics
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(5):514-520
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To study the effect of sex on the clinical outcome of extremely preterm infants (EPIs)/extremely low birth weight infants (ELBWIs) by propensity score matching.
METHODS:A retrospective analysis was performed for the medical data of 731 EPIs or ELBWIs who were admitted from January 1, 2011 to December 31, 2020. These infants were divided into two groups: male and female. A propensity score matching analysis was performed at a ratio of 1:1. The matching variables included gestational age, birth weight, percentage of withdrawal from active treatment, percentage of small-for-gestational-age infant, percentage of use of pulmonary surfactant, percentage of 1-minute Apgar score ≤3, percentage of mechanical ventilation, duration of mechanical ventilation, percentage of antenatal use of inadequate glucocorticoids, and percentage of hypertensive disorders in pregnancy. The two groups were compared in the incidence rate of main complications during hospitalization and the rate of survival at discharge.
RESULTS:Before matching, compared with the female group, the male group had significantly higher incidence rates of neonatal respiratory distress syndrome, bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, and patent ductus arteriosus (P<0.05), while after matching, the male group only had a significantly higher incidence rate of BPD than the female group (P<0.05). There was no significant difference in the rate of survival at discharge between the two groups before and after matching (P>0.05).
CONCLUSIONS:Male EPIs/ELBWIs have a higher risk of BPD than female EPIs/ELBWIs, but male and female EPIs/ELBWIs tend to have similar outcomes.
