Recent clinical research on the application of liquid biopsy in neuroblastoma.
10.7499/j.issn.1008-8830.2112120
- Author:
Si-Yang LIU
1
;
Fei-Qiu WEN
1
Author Information
1. Department of Pediatric Hematology and Oncology, Shenzhen Children's Hospital, China Medical University, Shenzhen, Guangdong 518000, China.
- Publication Type:Review
- Keywords:
Child;
Circulating tumor DNA;
Circulating tumor cell;
Exosome;
Liquid biopsy;
Neuroblastoma
- MeSH:
Child;
Humans;
Liquid Biopsy;
Neuroblastoma/diagnosis*
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(3):339-344
- CountryChina
- Language:English
-
Abstract:
Neuroblastoma (NB) is the most common extracranial solid tumor in children and has the features of high recurrence rate and low survival rate, and therefore, early diagnosis, treatment response evaluation, and recurrence monitoring are of great significance for NB patients. Liquid biopsy refers to the detection of cells and nucleic acids in fluid specimens, mainly blood. It is noninvasive and can overcome tumor heterogeneity, thus making it possible to achieve the early diagnosis and dynamic detection of NB. This review introduces the latest advances in clinical research on the application of liquid biopsy in NB.
