Change in intestinal flora after treatment in children with focal epilepsy.
10.7499/j.issn.1008-8830.2109134
- Author:
Shuai-Zheng GONG
1
;
Jun QIU
;
Li-Wen WU
;
Li-Hong TAN
Author Information
1. Department of Hematology and Oncology, Hunan Children's Hospital, Changsha 410007, China.
- Publication Type:Journal Article
- Keywords:
Child;
Epilepsy;
Focal seizure;
Intestinal flora
- MeSH:
Aged;
Bacteria/genetics*;
Child;
DNA, Bacterial;
Epilepsies, Partial/drug therapy*;
Gastrointestinal Microbiome;
Humans;
RNA, Ribosomal, 16S/genetics*
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(3):290-296
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the difference in intestinal flora between children with focal epilepsy and healthy children and the change in intestinal flora after treatment in children with epilepsy.
METHODS:A total of 10 children with newly diagnosed focal epilepsy were recruited as the case group and were all treated with oxcarbazepine alone. Their clinical data were recorded. Fecal specimens before treatment and after 3 months of treatment were collected. Fourteen aged-matched healthy children were recruited as the control group. Total bacterial DNA was extracted from the fecal specimens for 16S rDNA sequencing and bioinformatics analysis.
RESULTS:After 3 months of carbamazepine treatment, the seizure frequency was reduced by >50% in the case group. At the phylum level, the abundance of Actinobacteria in the case group before treatment was significantly higher than that in the control group (P<0.05), and it was reduced after treatment (P<0.05). At the genus level, the abundances of Escherichia/Shigella, Streptococcus, Collinsella, and Megamonas in the case group before treatment were significantly higher than those in the control group (P<0.05), and the abundances of these bacteria decreased significantly after treatment (P<0.05).
CONCLUSIONS:There is a significant difference in intestinal flora between children with focal epilepsy and healthy children. Oxcarbazepine can significantly improve the symptoms and intestinal flora in children with epilepsy.
