Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study.

Wei Shen; Zhi Zheng; Xin-zhu Lin; Fan WU; Qian-xin Tian; Qi-liang Cui; Yuan Yuan; Ling Ren; Jian Mao; Bi-zhen Shi; Yu-mei Wang; Ling Liu; Jing-hui Zhang; Yan-mei Chang; Xiao-mei Tong; Yan Zhu; Rong Zhang; Xiu-zhen YE; Jing-jing Zou; Huai-yu LI; Bao-yin Zhao; Yin-ping Qiu; Shu-hua Liu; Li MA; Ying XU; Rui Cheng; Wen-li Zhou; Hui WU; Zhi-yong Liu; Dong-mei Chen; Jin-zhi Gao; Jing Liu; Ling Chen; Cong LI; Chun-yan Yang; Ping XU; Ya-yu Zhang; Si-le HU; Hua Mei; Zu-ming Yang; Zong-tai Feng; San-nan Wang; Er-yan Meng; Li-hong Shang; Fa-lin XU; Shao-ping OU; Rong JU

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Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study.

Author: Wei SHEN ¹ ; Zhi ZHENG ¹ ; Xin-Zhu LIN ¹ ; Fan WU ¹ ; Qian-Xin TIAN ¹ ; Qi-Liang CUI ¹ ; Yuan YUAN ¹ ; Ling REN ¹ ; Jian MAO ¹ ; Bi-Zhen SHI ¹ ; Yu-Mei WANG ¹ ; Ling LIU ¹ ; Jing-Hui ZHANG ¹ ; Yan-Mei CHANG ¹ ; Xiao-Mei TONG ¹ ; Yan ZHU ¹ ; Rong ZHANG ¹ ; Xiu-Zhen YE ¹ ; Jing-Jing ZOU ¹ ; Huai-Yu LI ¹ ; Bao-Yin ZHAO ¹ ; Yin-Ping QIU ¹ ; Shu-Hua LIU ¹ ; Li MA ¹ ; Ying XU ¹ ; Rui CHENG ¹ ; Wen-Li ZHOU ¹ ; Hui WU ¹ ; Zhi-Yong LIU ¹ ; Dong-Mei CHEN ¹ ; Jin-Zhi GAO ¹ ; Jing LIU ¹ ; Ling CHEN ¹ ; Cong LI ¹ ; Chun-Yan YANG ¹ ; Ping XU ¹ ; Ya-Yu ZHANG ¹ ; Si-Le HU ¹ ; Hua MEI ¹ ; Zu-Ming YANG ¹ ; Zong-Tai FENG ¹ ; San-Nan WANG ¹ ; Er-Yan MENG ¹ ; Li-Hong SHANG ¹ ; Fa-Lin XU ¹ ; Shao-Ping OU ¹ ; Rong JU ¹
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1. Department of Neonatology, Women's and Children's Hospital Affiliated to Xiamen University/Xiamen Maternal and Child Health Hospital, Xiamen, Fujian 361003, China.
Collective Name:Nutritional Committee of Neonatology Branch of ChineseMedical Doctor Association, National Multicenter EUGR Collaborative Group
Publication Type:Multicenter Study
Keywords: Extrauterine growth retardation; Nutrition; Risk factor; Very preterm infant
MeSH: Female; Fetal Growth Retardation; Gestational Age; Hospitalization; Humans; Incidence; Infant; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Prospective Studies; Risk Factors
From: Chinese Journal of Contemporary Pediatrics 2022;24(2):132-140
CountryChina
Language:English
Abstract: OBJECTIVES:To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization in China.
METHODS:A prospective multicenter study was performed on the medical data of 2 514 VPIs who were hospitalized in the department of neonatology in 28 hospitals from 7 areas of China between September 2019 and December 2020. According to the presence or absence of EUGR based on the evaluation of body weight at the corrected gestational age of 36 weeks or at discharge, the VPIs were classified to two groups: EUGR group (n=1 189) and non-EUGR (n=1 325). The clinical features were compared between the two groups, and the incidence of EUGR and risk factors for EUGR were examined.
RESULTS:The incidence of EUGR was 47.30% (1 189/2 514) evaluated by weight. The multivariate logistic regression analysis showed that higher weight growth velocity after regaining birth weight and higher cumulative calorie intake during the first week of hospitalization were protective factors against EUGR (P<0.05), while small-for-gestational-age birth, prolonged time to the initiation of total enteral feeding, prolonged cumulative fasting time, lower breast milk intake before starting human milk fortifiers, prolonged time to the initiation of full fortified feeding, and moderate-to-severe bronchopulmonary dysplasia were risk factors for EUGR (P<0.05).
CONCLUSIONS:It is crucial to reduce the incidence of EUGR by achieving total enteral feeding as early as possible, strengthening breastfeeding, increasing calorie intake in the first week after birth, improving the velocity of weight gain, and preventing moderate-severe bronchopulmonary dysplasia in VPIs.