Risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children: a Meta analysis.
10.7499/j.issn.1008-8830.2109025
- Author:
Bi-Yu LIN
1
;
Jing-Ting LIU
1
;
Feng-Ling JIN
1
Author Information
1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
- Publication Type:Meta-Analysis
- Keywords:
Carbapenem-resistant Enterobacteriaceae;
Child;
Colonization;
Infection;
Meta analysis;
Risk factor
- MeSH:
Anti-Bacterial Agents/therapeutic use*;
Carbapenem-Resistant Enterobacteriaceae;
Carbapenems/pharmacology*;
Child;
Enterobacteriaceae Infections/microbiology*;
Humans;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(1):96-101
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To systematically assess the risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children.
METHODS:PubMed, Web of Science, China National Knowledge Infrastructure Database, Wanfang Data, China Biology Medicine disc were searched to obtain the articles on risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children published up to May 31, 2021. RevMan 5.3 software was used to perform the Meta analysis.
RESULTS:A total of 13 articles were included, with 1 501 samples in total. The Meta analysis showed that indwelling gastric tube (OR=4.91), tracheal intubation (OR=5.03), central venous catheterization (OR=3.75), indwelling urinary catheterization (OR=4.11), mechanical ventilation (OR=3.09), history of hospitalization in the intensive care unit (OR=2.39), history of surgical operation (OR=3.22), previous use of third-generation cephalosporins (OR=2.62), previous use of carbapenem antibiotics (OR=3.82), previous use of glycopeptide antibiotics (OR=3.48), previous use of β-lactamase inhibitors (OR=2.87), previous use of antifungal drugs (OR=2.48), previous use of aminoglycoside antibiotics (OR=2.54), and Apgar score ≤7 at 1 minute after birth (OR=2.10) were risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children (P<0.05).
CONCLUSIONS:Invasive operations, history of hospitalization in the intensive care unit, previous use of antibiotics such as carbapenem antibiotics, and Apgar score ≤7 at 1 minute after birth are risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children.
