Clinical treatment outcomes and their changes in extremely preterm twins: a multicenter retrospective study in Guangdong Province, China.
- Author:
Bi-Jun SHI
1
;
Ying LI
1
;
Fan WU
1
;
Zhou-Shan FENG
1
;
Qi-Liang CUI
1
;
Chuan-Zhong YANG
;
Xiao-Tong YE
;
Yi-Heng DAI
;
Wei-Yi LIANG
;
Xiu-Zhen YE
;
Jing MO
;
Lu DING
;
Ben-Qing WU
;
Hong-Xiang CHEN
;
Chi-Wang LI
;
Zhe ZHANG
;
Xiao RONG
;
Wei SHEN
;
Wei-Min HUANG
;
Bing-Yan YANG
;
Jun-Feng LYU
;
Hui-Wen HUANG
;
Le-Ying HUO
;
Hong-Ping RAO
;
Wen-Kang YAN
;
Xue-Jun REN
;
Yong YANG
;
Fang-Fang WANG
;
Dong LIU
;
Shi-Guang DIAO
;
Xiao-Yan LIU
;
Qiong MENG
;
Yu WANG
;
Bin WANG
;
Li-Juan ZHANG
;
Yu-Ge HUANG
;
Dang AO
;
Wei-Zhong LI
;
Jie-Ling CHEN
;
Yan-Ling CHEN
;
Wei LI
;
Zhi-Feng CHEN
;
Yue-Qin DING
;
Xiao-Yu LI
;
Yue-Fang HUANG
;
Ni-Yang LIN
;
Yang-Fan CAI
;
Sha-Sha HAN
;
Ya JIN
;
Guo-Sheng LIU
;
Zhong-He WAN
;
Yi BAN
;
Bo BAI
;
Guang-Hong LI
;
Yue-Xiu YAN
Author Information
- Collective Name:Collaboration Study Group for Extremely Preterm and Extremely Low Birth Weight Infants
- Publication Type:Multicenter Study
- Keywords: Birth weight; Complication; Extremely preterm infant; Mortality rate; Twins
- MeSH: Bronchopulmonary Dysplasia/epidemiology*; Female; Gestational Age; Humans; Infant; Infant, Extremely Premature; Infant, Newborn; Pregnancy; Respiratory Distress Syndrome, Newborn/epidemiology*; Retrospective Studies; Treatment Outcome
- From: Chinese Journal of Contemporary Pediatrics 2022;24(1):33-40
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To investigate the clinical treatment outcomes and the changes of the outcomes over time in extremely preterm twins in Guangdong Province, China.
METHODS:A retrospective analysis was performed for 269 pairs of extremely preterm twins with a gestational age of <28 weeks who were admitted to the department of neonatology in 26 grade A tertiary hospitals in Guangdong Province from January 2008 to December 2017. According to the admission time, they were divided into two groups: 2008-2012 and 2013-2017. Besides, each pair of twins was divided into the heavier infant and the lighter infant subgroups according to birth weight. The perinatal data of mothers and hospitalization data of neonates were collected. The survival rate of twins and the incidence rate of complications were compared between the 2008-2012 and 2013-2017 groups.
RESULTS:Compared with the 2008-2012 group, the 2013-2017 group (both the heavier infant and lighter infant subgroups) had lower incidence rates of severe asphyxia and smaller head circumference at birth (P<0.05). The mortality rates of both of the twins, the heavier infant of the twins, and the lighter infant of the twins were lower in the 2013-2017 group compared with the 2008-2012 group (P<0.05). Compared with the 2008-2012 group, the 2013-2017 group (both the heavier infant and lighter infant subgroups) had lower incidence rates of pulmonary hemorrhage, patent ductus arteriosus (PDA), periventricular-intraventricular hemorrhage (P-IVH), and neonatal respiratory distress syndrome (NRDS) and a higher incidence rate of bronchopulmonary dysplasia (P<0.05).
CONCLUSIONS:There is a significant increase in the survival rate over time in extremely preterm twins with a gestational age of <28 weeks in the 26 grade A tertiary hospitals in Guangdong Province. The incidences of severe asphyxia, pulmonary hemorrhage, PDA, P-IVH, and NRDS decrease in both the heavier and lighter infants of the twins, but the incidence of bronchopulmonary dysplasia increases. With the improvement of diagnosis and treatment, the multidisciplinary collaboration between different fields of fetal medicine including prenatal diagnosis, obstetrics, and neonatology is needed in the future to jointly develop management strategies for twin pregnancy.
