Research progress of cross-disease miRNA molecular markers in schizophrenia, bipolar disorder and depression.
10.3760/cma.j.cn511374-20210314-00221
- Author:
Yanni MA
1
;
Chengcheng ZHANG
Author Information
1. Mental Health Center of West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. zhangcc89@foxmail.com.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
Bipolar Disorder/genetics*;
Depression/genetics*;
Humans;
MicroRNAs;
Schizophrenia/genetics*
- From:
Chinese Journal of Medical Genetics
2022;39(5):548-554
- CountryChina
- Language:Chinese
-
Abstract:
Micro non-coding RNA (microRNA, miRNA) is a small non-coding RNA involved in gene expression regulation that plays an important role in the onset and development of mental illness. Evidence suggests that several miRNAs are dysregulated in patients with mental illnesses. Because of its stability and quantitative detection in peripheral blood and cerebral fluid, miRNA is a particularly attractive biomarker. The objective of this research is to investigate the relationship between mental illness and miRNAs, as well as the potential processes through which miRNAs contribute to disease etiology. Schizophrenia, bipolar disorder, and depression are three major mental disorders with high disability and mortality. The study explored the particular dysregulated miRNAs for each condition as well as common dysregulated miRNAs across diseases. In this study, which analyzes the findings from relevant studies from 2016 to 2020, the authors discuss the functions of numerous severely dysfunctional miRNAs and their application potential in the field of psychiatry research.
