Enlarged multicystic dysplastic kidneys with oligohydramnios during infancy caused by NPHP3 gene mutation.
10.3760/cma.j.cn511374-20210810-00662
- VernacularTitle:NPHP3基因变异导致胎儿肾囊肿伴严重羊水减少的诊断研究
- Author:
Youwei BAO
1
;
Xiaoli PAN
;
Shuqing PAN
;
Danyan ZHUANG
;
Haibo LI
;
Qitian MU
;
Lulu YAN
Author Information
1. Ningbo University School of Medicine, Ningbo, Zhejiang 315211, China. muqitian@163.com.
- Publication Type:Journal Article
- MeSH:
Amniotic Fluid;
Female;
Humans;
Kidney Diseases, Cystic;
Multicystic Dysplastic Kidney/genetics*;
Mutation;
Oligohydramnios/genetics*;
Polycystic Kidney Diseases;
Pregnancy;
Ultrasonography, Prenatal
- From:
Chinese Journal of Medical Genetics
2022;39(5):510-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical features and genomic abnorm ality of a fetus enlarged multicystic dysplastic kidneys with oligohydramnios caused by NPHP3 gene mutation.
METHODS:The fetuse was found to have multicystic dysplastic kidneys with oligohydramnios upon ultrasonography during the second trimester. Following induced abortion, fetal tissue was collected for the extraction of DNA, chromosomal microarray analysis (CMA) and whole exome sequencing (WES). Sanger sequencing was used to verify the suspected variants in the family.
RESULTS:Antenatal ultrasound examination at 19 weeks showed "polycystic" kidneys with Oligohydramnios. Delivery was by induced labour because of the critically low amniotic fluid volume. Testing of CMA was normal. WES showed a compound heterozygous mutation of c.1817G>A, p.W606X; c.432dupA, p.E145Rfs*18 mutations are novel mutations in this study.
CONCLUSION:The research may further expand the NPHP3 gene mutation spectrum. Enlarged multicystic dysplastic kidneys with oligohydramnios caused by NPHP3 gene mutation at least include one or two splice site mutation, frameshift mutation or nonsense mutation foetal poor prognosis.
