Y chromosome-related genetic diseases.
10.3760/cma.j.cn511374-20210402-00294
- VernacularTitle:Y染色体相关遗传病
- Author:
Linwei YIN
1
;
Jing GUAN
;
Qiuju WANG
Author Information
1. Hebei Industrial Technology Research Institute of Genomics in Maternal & Child Health, Shijiazhuang,Hebei 050000, China. wqcr301@vip.sina.com.
- Publication Type:Journal Article
- MeSH:
Chromosomes, Human, Y/genetics*;
Humans;
Male
- From:
Chinese Journal of Medical Genetics
2022;39(3):350-354
- CountryChina
- Language:Chinese
-
Abstract:
As a male-specific chromosome, the structure of Y chromosome is complex and lacks of recombination, with numerous repeating, amplifying and palindromic sequences. The research of Y chromosome is difficult and slow since there are few protein coding genes and a large amount of heterochromatin which has caused extreme difficulty for sequencing. In recent years, an increasing number of studies have been focused on the Y chromosome. With the completion of the sequencing of human Y chromosome, the rapid development of sequencing technology, and the composition of DNA sequences in human Y chromosomes and the determination of gene content. This paper has summarized the structural composition and genes function of human Y chromosome, as well as the related hereditary diseases, with an aim to provide reference for Y chromosome-related genetic research.
