Identification of a rare platelet-specific antigen HPA-10bw allele among ethnic Han Chinese population in Shandong.
10.3760/cma.j.cn511374-20210318-00241
- Author:
Jingru SHAO
1
;
Wenchao LI
;
Yingfang PAN
;
Wenben QIAO
;
Chuanfu ZHU
;
Xiangmin NIE
;
Yan LIU
Author Information
1. Blood Center of Shandong Province, Jinan, Shandong 250014, China. sd1866011@163.com.
- Publication Type:Journal Article
- MeSH:
Alleles;
Antigens, Human Platelet/genetics*;
Asians/genetics*;
Gene Frequency;
Genotype;
Humans;
Infant, Newborn;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2022;39(2):231-233
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the polymorphism of human platelet antigen (HPA) system 10 among ethnic Han Chinese from Shandong, China so as to supplement the data of platelet donor bank in the region.
METHODS:Peripheral blood samples of platelet donors from the region were genotyped for HPA-10 alleles by PCR-sequence specific primer (PCR-SSP) and direct sequencing.
RESULTS:Among 1401 donors, a rare heterozygote carrier of HPA-10w (a+b+) was identified, which gave an allelic frequency of approximately 0.035%.
CONCLUSION:The detection of rare HPA-10bw antigen allele among ethnic Han Chinese from Shandong is useful for the diagnosis and prevention of neonatal alloimmune thrombocytopenia and post-transfusion purpura in the region.
