Research progress of Notch signaling pathway in spinal cord injury.
10.12200/j.issn.1003-0034.2022.02.019
- Author:
Jing LI
1
;
Jia-Xi LI
1
;
Xi-Jing HE
1
;
Hua-You CHEN
1
;
Hang ZHAO
1
Author Information
1. The Second Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
- Publication Type:Journal Article
- Keywords:
Notch signaling pathway;
Review;
Spinal cord injury
- MeSH:
Axons/metabolism*;
Cell Transplantation;
Humans;
Nerve Regeneration;
Signal Transduction/genetics*;
Spinal Cord/metabolism*;
Spinal Cord Injuries/metabolism*
- From:
China Journal of Orthopaedics and Traumatology
2022;35(2):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a severe central nervous system disease, which will cause a series of complex pathophysiological changes and activate a variety of signaling pathways including Notch signaling. Studies have evidenced that activation of the Notch signaling pathway is not conducive to nerve repair and symptom improvement after spinal cord injury. Its mechanisms include inhibiting neuronal differentiation and axon regeneration, promoting reactive astrocyte proliferation, promoting M1 macrophage polarization and the release of proinflammatory factors, and inhibiting angiogenesis. Therefore, it has become a promising therapeutic strategy to inhibit Notch signal as a target in the treatment of spinal cord injury. In recent years, some researchers have used drugs, cell transplantation or genetic modification to regulate Notch signaling, which can promote the recovery of nerve function after spinal cord injury, thereby providing new treatment strategies for the treatment of spinal cord injury. This article will summarize the mechanism of Notch signaling pathway in spinal cord injury, and at the same time review the research progress in the treatment of spinal cord injury by modulating Notch signaling pathway in recent years, so as to provide new research ideas for further exploring new strategies for spinal cord injury.
