Research Advances in the Role of Keratins in Gastrointestinal Cancer.

Author: Siwen OUYANG ¹ ; Wei-Ming KANG ²
Author Information

1. Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
2. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100010, China.
Publication Type:Review
Keywords: Keratin; diagnostic significance; gastrointestinal cancer; mechanism
MeSH: Biomarkers, Tumor; Gastrointestinal Neoplasms/therapy*; Humans; Keratins
From: Chinese Medical Sciences Journal 2022;37(1):73-78
CountryChina
Language:English
Abstract: The incidence and mortality rates of gastrointestinal (GI) cancer remain high. Despite constant improvements in diagnostic and therapeutic techniques, the early diagnosis, mid- and late-stage treatment, drug tolerance, and cancer recurrence and metastasis in GI cancer remain challenging. In this review article we summarize the recent research advance in the roles of keratins in GI cancer, with the hope that they will become efficient biomarkers for the prediction, diagnosis, or treatment of these malignancies.