Replacement Therapy for Hemophilia Patients Undergoing Cardiac Surgery: Report of Three Cases.

Xiaokun Chen; Qi Miao; Tie-nan Zhu; Chao-ji Zhang

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Replacement Therapy for Hemophilia Patients Undergoing Cardiac Surgery: Report of Three Cases.

Author: Xiaokun CHEN ¹ ; Qi MIAO ² ; Tie-Nan ZHU ³ ; Chao-Ji ZHANG ²
Author Information

1. Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
2. Department of Cardiac Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
3. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Publication Type:Journal Article
Keywords: Hemophilia; cardiac surgery; replacement therapy
MeSH: Cardiac Surgical Procedures/adverse effects*; Cardiopulmonary Bypass; Hemophilia A/complications*; Humans
From: Chinese Medical Sciences Journal 2022;37(1):79-81
CountryChina
Language:English
Abstract: Hemophilia is an X-linked recessive inherited bleeding disorder. Despite the improved treatment in recent years with the advent of replacement therapies, the progression of atherosclerosis is not slowed down after the reduction of clotting factors in hemophilia. As life expectancy increases, more hemophilia patients will suffer from age-related cardiovascular diseases. Since cardiac surgery needs heparinization and cardiopulmonary bypass (CPB), it is extremely challenging to balance hemostasis and coagulation in patients with hemophilia. Here we report three cases of hemophilia patients who underwent cardiac surgery successfully.