Ultrasound-Guided Continuous Thoracic Paravertebral Block Improves Patient's Quality of Recovery After Open Hepatectomy: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Author:
Xu-Lei CUI
1
;
Nan XU
1
;
Zhi-Yong ZHANG
1
;
Bo ZHU
1
;
Yue-Lun ZHANG
2
;
Yong-Chang ZHENG
3
;
Shun-da DU
3
;
Yi-Lei MAO
3
;
Xin-Ting SANG
3
;
Yu-Guang HUANG
1
Author Information
- Publication Type:Randomized Controlled Trial
- Keywords: hepatectomy; quality of recovery; ropivacaine; thoracic paravertebral block
- MeSH: Anesthetics, Local/therapeutic use*; Double-Blind Method; Hepatectomy/adverse effects*; Humans; Morphine/therapeutic use*; Pain Measurement; Pain, Postoperative/etiology*; Ultrasonography, Interventional
- From: Chinese Medical Sciences Journal 2022;37(1):15-22
- CountryChina
- Language:English
- Abstract: Background Ultrasound-guided continuous thoracic paravertebral block can provide pain-relieving and opioid-sparing effects in patients receiving open hepatectomy. We hypothesize that these effects may improve the quality of recovery (QoR) after open hepatectomy. Methods Seventy-six patients undergoing open hepatectomy were randomized to receive a continuous thoracic paravertebral block with ropivacaine (CTPVB group) or normal saline (control group). All patients received patient-controlled intravenous analgesia with morphine postoperatively for 48 hours. The primary outcome was the global Chinese 15-item Quality of Recovery score on postoperative day 7, which was statistically analyzed using Student's t-test. Results Thirty-six patients in the CTPVB group and 37 in the control group completed the study. Compared to the control group, the CTPVB group had significantly increased global Chinese 15-item Quality of Recovery scores (133.14 ± 12.97 vs. 122.62 ± 14.89, P = 0.002) on postoperative day 7. Postoperative pain scores and cumulative morphine consumption were significantly lower for up to 8 and 48 hours (P < 0.05; P = 0.002), respectively, in the CTPVB group. Conclusion Perioperative CTPVB markably promotes patient's QoR after open hepatectomy with a profound analgesic effect in the early postoperative period.
