Q-markers of Yuquan Capsules based on serum pharmacochemistry of Chinese medicine.
10.19540/j.cnki.cjcmm.20211207.203
- Author:
Tai-Ping LI
1
;
Zhi-En TAN
2
;
Meng-Li ZHANG
2
;
Min OU
2
;
Yan-Mei HE
3
;
Fang-Fang WU
2
Author Information
1. National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants Nanning 530023, China National Chinmedomics Research Center, Heilongjiang University of Chinese Medicine Harbin 150040, China.
2. National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants Nanning 530023, China.
3. National Chinmedomics Research Center, Heilongjiang University of Chinese Medicine Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
UPLC-Q-TOF-MS;
Yuquan Capsules;
quality markers(Q-markers);
serum pharmacochemistry of Chinese medicine
- MeSH:
Capsules;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal/pharmacology*;
Ginsenosides/analysis*;
Medicine, Chinese Traditional;
Serum/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(7):1802-1813
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzed the quality markers(Q-markers) of Yuquan Capsules(YQC) based on serum pharmacochemistry of Chinese medicine and detected the components and metabolites of YQC absorbed into the blood by UPLC-Q-TOF-MS and UNIFI systems. As a result, 32 components of YQC were detected, including 17 prototype components and 15 metabolized components. Among them, 12 prototype components(ginsenoside Rh_2, genistein, formononetin, puerarin, daidzein, schizandrin A, schizandrin B, schizandrin C, schizandrol A, schizandrol B, gomisin D, and ononin) and 12 metabolized components(ginsenoside Rg_1, ginsenoside Rg_2, ginsenoside Rg_3, ginsenoside Ro, 3'-methoxypuerarin, daidzin, astragaloside Ⅱ, astragaloside Ⅳ, glycyrrhizic acid, liquiritigenin, isoliquiritin, and verbascoside) showed inhibitory effects and pharmacological activities against diabetes, and these 24 blood-entering components against diabetes were identified as Q-markers of YQC.
