Research progress on Astragali Radix and prediction of its quality markers (Q-markers).
10.19540/j.cnki.cjcmm.20211213.201
- Author:
Yu-Ting DAI
1
;
Xue-Yan ZHANG
1
;
Yi-Xuan WANG
1
;
Yong-Sheng FAN
2
;
Dan YANG
2
;
Yong-Qi LIU
3
;
Ming-Hui XIU
4
;
Jian-Zheng HE
5
Author Information
1. School of Public Health, Gansu University of Chinese Medicine Lanzhou 730000, China.
2. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
3. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China Key Laboratory of Dunhuang Medicine and Transformation Ministry of Education, Gansu University of Chinese Medicine Lanzhou 730000, China.
4. School of Public Health, Gansu University of Chinese Medicine Lanzhou 730000, China Key Laboratory of Dunhuang Medicine and Transformation Ministry of Education, Gansu University of Chinese Medicine Lanzhou 730000, China.
5. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China Key Laboratory of Dunhuang Medicine and Transformation Ministry of Education, Gansu University of Chinese Medicine Lanzhou 730000, China School of Basic Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
- Publication Type:Review
- Keywords:
Astragali Radix;
Astragalus polysaccharides;
astragaloside Ⅳ;
calycosin;
calycosin-7-O-β-D-glucoside;
formononetin;
ononin;
quality markers(Q-markers)
- MeSH:
Astragalus Plant;
Chromatography, High Pressure Liquid/methods*;
Drugs, Chinese Herbal/pharmacology*;
Flavonoids;
Plant Roots
- From:
China Journal of Chinese Materia Medica
2022;47(7):1754-1764
- CountryChina
- Language:Chinese
-
Abstract:
Astragali Radix, a medicinal herb for invigorating Qi, has anti-aging, anti-tumor, immunoregulatory, blood sugar-and lipid-lowering, anti-fibrosis, anti-radiation and other pharmacological effects. This article reviewed the studies about the chemical components and pharmacological effects of Astragali Radix. According to the theory of quality markers(Q-markers) of Chinese medicinal materials, we predicted the Q-markers of Astragali Radix from traditional efficacy, chemical component validity, measurability, plant phylogeny, and pharmacokinetis. The results showed that total polysaccharides, flavonoids(e.g., calycosin-7-O-β-D-glucoside, formononetin, calycosin, quercetin, and ononin), and saponins(e.g., astragalosides Ⅱ, Ⅲ, and Ⅳ) can be taken as the main Q-markers. This review lays a foundation for regulating the quality research and standard establishment of Astragali Radix, and benefits the control and quality supervision of the production process of Astragali Radix and its related products.
