Research progress of Curcuma kwangsiensis root tubers and analysis of liver protection and anti-tumor mechanisms based on Q-markers.
10.19540/j.cnki.cjcmm.20211220.203
- Author:
Ze-Yu LI
1
;
Er-Wei HAO
1
;
Zheng-Cai DU
1
;
Rui CAO
1
;
Feng CHEN
1
;
Liu-Ying MO
1
;
Dong-Yang WU
1
;
Xiao-Tao HOU
2
;
Jia-Gang DENG
1
Author Information
1. China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Nanning 530200, China Guangxi Key Laboratory of Traditional Chinese Medicine Rheumatism Prescription Theory and Transformation Nanning 530200, China Guangxi Scientific Research Center of Traditional Chinese Medicine Nanning 530200, China.
2. China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Nanning 530200, China Guangxi Key Laboratory of Traditional Chinese Medicine Rheumatism Prescription Theory and Transformation Nanning 530200, China Guangxi Scientific Research Center of Traditional Chinese Medicine Nanning 530200, China College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China.
- Publication Type:Review
- Keywords:
Curcuma kwangsiensis root tubers;
Curcumae Radix;
chemical composition;
curcumadiol;
curcumenol;
curcumin;
curcumol;
curdione;
germacrone;
pharmacological action;
quality marker(Q-marker);
quality standard;
β-elemene
- MeSH:
China;
Curcuma/chemistry*;
Humans;
Liver;
Neoplasms;
Terpenes/pharmacology*
- From:
China Journal of Chinese Materia Medica
2022;47(7):1739-1753
- CountryChina
- Language:Chinese
-
Abstract:
Curcuma kwangsiensis root tuber is a widely used genuine medicinal material in Guangxi, with the main active components of terpenoids and curcumins. It has the effects of promoting blood circulation to relieve pain, moving Qi to relieve depression, clearing heart and cooling blood, promoting gallbladder function and anti-icterus. Modern research has proved its functions in liver protection, anti-tumor, anti-oxidation, blood lipid reduction and immunosuppression. Considering the research progress of C. kwangsiensis root tubers and the core concept of quality marker(Q-marker), we predicted the Q-markers of C. kwangsiensis root tubers from plant phylogeny, chemical component specificity, traditional pharmacodynamic properties, new pharmacodynamic uses, chemical component measurability, processing methods, compatibility, and components migrating to blood. Curcumin, curcumol, curcumadiol, curcumenol, curdione, germacrone, and β-elemene may be the possible Q-markers. Based on the predicted Q-markers, the mechanisms of the liver-protecting and anti-tumor activities of C. kwangsiensis root tubers were analyzed. AKT1, IL6, EGFR, and STAT3 were identified as the key targets, and neuroactive ligand-receptor interaction signaling pathway, nitrogen metabolism pathway, cancer pathway, and hepatitis B pathway were the major involved pathways. This review provides a basis for the quality evaluation and product development of C. kwangsiensis root tubers and gives insights into the research on Chinese medicinal materials.
