Analysis and prediction of quality markers of Lonicerae Japonicae Flos.
10.19540/j.cnki.cjcmm.20211224.201
- Author:
Yue YUAN
1
;
Lin-Lin ZHANG
2
;
Jian-Ting LIU
3
;
Hong-Bing ZHANG
3
;
Jun XU
2
;
Tie-Jun ZHANG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
2. Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China.
3. Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China.
- Publication Type:Journal Article
- Keywords:
Lonicerae Japonicae Flos;
chemical basis;
pharmacological action;
quality evaluation;
quality marker(Q-marker)
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal/chemistry*;
Flowers/chemistry*;
Lonicera/chemistry*;
Phylogeny;
Quality Control
- From:
China Journal of Chinese Materia Medica
2022;47(7):1730-1738
- CountryChina
- Language:Chinese
-
Abstract:
Lonicerae Japonicae Flos, as common Chinese medicine, has been used for thousands of years in the treatment of inflammation and infectious diseases with definite efficacies. The complex composition of Lonicerae Japonicae Flos results in its extensive pharmacological effects, so the assessment of its quality by only a few index components is not comprehensive. Guided by the quality marker(Q-marker), the present study comprehensively analyzed and predicted the quality connotation of Lonicerae Japonicae Flos based on the chemical composition and component transfer, the phylogenetic relationship, chemical composition effectiveness, measurability, and specificity. Chlorogenic acid, isochlorogenic acids A, B, and C, luteoloside, rutin, sweroside, and secoxyloganin were predicted as candidate Q-markers of Lonicerae Japonicae Flos.
