Trace therapeutic substances of traditional Chinese medicine: great resources of innovative drugs derived from traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20220210.201
- Author:
Xiao-Feng XIA
1
;
Gui-Yang XIA
1
;
Yu-Zhuo WU
1
;
Huan XIA
1
;
Ling-Yan WANG
1
;
Hong-Cai SHANG
1
;
Sheng LIN
1
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
- Publication Type:Review
- Keywords:
innovative drugs;
trace therapeutic substances;
traditional Chinese medicine
- MeSH:
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2022;47(7):1705-1729
- CountryChina
- Language:Chinese
-
Abstract:
The traditional Chinese medicine(TCM) contains very complex constituents. Besides the major constituents, there are a large number of unclear trace constituents with novel skeletons and potent bioactivities, which have been regarded as one of the important therapeutic substances and the great resources of innovative drugs derived from TCM. The present review highlighted that the development of the trace therapeutic substances of TCM is closely depends on the advanced technologies for their identification, isolation, structure elucidation, and bioactivity evaluation. Additionally, this paper reviewed the novel trace compounds derived from Chinese herbal medicines which have been published in Organic Letters during 2001-2021, and summarized the important licensed drugs originated from the trace therapeutic substances and the discovery and development of trace therapeutic substances of 8 kinds of Chinese herbal medicines. This review provides references for the research and development of TCM therapeutic substances and innovative drugs.
