Secondary metabolites of endophyte fungi Xylaria sp. from Coptis chinensis.
10.19540/j.cnki.cjcmm.20220207.201
- Author:
Guo-Ping YIN
1
;
Ya-Juan LI
1
;
Bo LI
1
;
Xue-Mei LIU
1
;
Jing-Jing ZHU
2
;
Zhi-Min WANG
2
;
Chang-Hua HU
1
Author Information
1. Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University Chongqing 400716, China.
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Coptis chinensis;
Xylaria sp.;
lasobutone A;
lasobutone B
- MeSH:
Antineoplastic Agents;
Coptis chinensis;
Endophytes/chemistry*;
Fungi;
Polyketides/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(8):2165-2169
- CountryChina
- Language:Chinese
-
Abstract:
Two new polyketides, lasobutone A(1) and lasobutone B(2), along with three known compounds, guignardianone C(3), guignardic acid(4), and 4-hydroxy-17R-methylincisterol(5), were isolated from the endophytic fungi Xylaria sp. by silica gel, MCI, and preparative HPLC, which was separated from the Chinese medicinal material Coptis chinensis and cultivated through solid fermentation with rice. Their structures were elucidated on the basis of spectroscopic methods, such as MS, NMR, IR, UV, and ECD. Compounds 2 and 4 showed inhibitory activities against the nitric oxide(NO) production in the LPS-induced macrophage RAW264.7 with IC_(50) values of 58.7 and 42.5 μmol·L~(-1) respectively, while compound 5 exhibited cytotoxic activities against HT-29 with IC_(50) value of 14.3 μmol·L~(-1).
