Research model integrating "both medicinal and adjuvant properties" for essential oils from Chinese medicinal: based on characterization of medicinal properties.
10.19540/j.cnki.cjcmm.20211202.601
- Author:
Jun CHEN
1
;
Jun-Hong YAO
2
;
Yi-Wei WANG
1
;
Mei DONG
2
;
Shan-Shan LU
2
;
Guo-Jun YAN
2
;
Jin-Ao DUAN
3
Author Information
1. Jiangsu Provincial Enginerring Research Center of Traditional Chinese Medicine (TCM) External Medication Development and Application, Nanjing University of Chinese Medicine Nanjing 210023, China Collaborative Innovation Center for the Industrialization Process of Traditional Chinese Medicine Resources in Jiangsu Province, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. Jiangsu Provincial Enginerring Research Center of Traditional Chinese Medicine (TCM) External Medication Development and Application, Nanjing University of Chinese Medicine Nanjing 210023, China.
3. Collaborative Innovation Center for the Industrialization Process of Traditional Chinese Medicine Resources in Jiangsu Province, Nanjing University of Chinese Medicine Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
characterization of drug property;
essential oils from Chinese medicinal;
external application via skin;
integrating both medicinal and adjuvant properties
- MeSH:
Adjuvants, Pharmaceutic;
Administration, Cutaneous;
China;
Drugs, Chinese Herbal/pharmacology*;
Oils, Volatile/pharmacology*
- From:
China Journal of Chinese Materia Medica
2022;47(8):2015-2020
- CountryChina
- Language:Chinese
-
Abstract:
Essential oils(EOs) from Chinese medicinals, which can be used as adjuvants and exert certain therapeutic effect, are directly used in Chinese medicine formulas. Conventional research strategy for EOs from Chinese medicinals is to compare the efficacy of the prescriptions before and after the addition of EOs, and the penetration-enhancing mechanisms of EOs remain unclear. In modern research on EOs from Chinese medicinals, the method for studying chemical penetration enhancers is often used, which fails to reflect the overall efficacy of EOs. This study clarified the property regularity of EOs from Chinese medicinals as transdermal penetration enhancers, and thereby proposed a research model which integrated the medicinal and adjuvant properties of EOs from Chinese medicinals via "component-delivery-effect" characterization route. The core concept is that constituents of EOs from Chinese medicinals and their delivery process play a key role in their external application. This research model is expected to serve as a reference for further research on EOs from Chinese medicinals for transdermal application.
