Compatibility for toxicity attenuation of toxic traditional Chinese medicine: a review and strategies.
10.19540/j.cnki.cjcmm.20220105.401
- Author:
Yue GAO
1
;
Chuan LI
2
;
Ai-Hua LIANG
3
;
Xiu-Mei GAO
4
;
Yan-Ling ZHAO
5
Author Information
1. Institute of Radiation Medicine Sciences, Academy of Military Medical, Academy of Military Sciences Beijing 100850, China.
2. Shanghai Institute of Materia Medica, China Academy of Sciences Shanghai 201203, China.
3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
4. Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
5. China Military Institute of Chinese Materia Medica Beijing 100039, China.
- Publication Type:Review
- Keywords:
commonly used prescriptions in clinic;
strategy;
toxic traditional Chinese medicine;
toxicity attenuation with compatibility
- MeSH:
Drugs, Chinese Herbal/toxicity*;
Medicine, Chinese Traditional;
Research Design
- From:
China Journal of Chinese Materia Medica
2022;47(8):1989-1994
- CountryChina
- Language:Chinese
-
Abstract:
Toxicity-attenuating compatibility is an effective measure to ensure the safety of Chinese medicine. Involving the origin, processing method, compatibility mode, and dosage, it faces multiple challenges, such as the uncertainty of toxic substances, toxicity latency, indefinite safe dose, complex toxicity-efficacy relationship, and individual difference. As a result, research on clinical safety of Chinese medicine is limited by the consistency at "molecular-cellular-organ-overall" levels, unclear interaction of multiple medicinals and multiple substances, the "toxicity-efficacy-compatibility-syndrome" correlation, and the "dosage-time-toxicity-efficacy" conversion law. Therefore, following the principle of "starting from the clinical practice, verifying via the theoretical basis, and finally applying in clinical practice", we verified the toxicity at "molecular-cellular-organ-overall" levels, revealed the interaction of multiple medicinals and substances, collected evidence at multiple levels, clarified the "dosage-time-toxicity-efficacy" relationship, and tested the consistency between basic and clinical biomarkers. On this basis, we studied the toxicity-alleviating and efficacy-enhancing(preserving) compatibility characteristics, the fate of one medicinal and multiple medicinals in vivo, the molecular mechanism of toxicity, the "dosage-time-toxicity-efficacy" conversion law, and the clinical characteristics of toxic traditional Chinese medicine based on disease and syndrome. The three mechanisms of toxicity-attenuating compatibility reflect the seven-reaction theory in Chinese medicine compatibility. Finally, the strategies for safe use of Chinese medicine were proposed.
