Meta-analysis of Bailing Capsules in improvement of microinflammation and nutritional status among maintenance hemodialysis patients.
10.19540/j.cnki.cjcmm.20211222.501
- Author:
Xiao-Jing HU
1
;
Bing CUI
1
;
Qing GAO
2
;
Zhi-Jie WANG
1
;
Yu-Nan LIU
3
Author Information
1. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
2. Henan University of Chinese Medicine Zhengzhou 450000, China.
3. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China Henan University of Chinese Medicine Zhengzhou 450000, China.
- Publication Type:Meta-Analysis
- Keywords:
Bailing Capsules;
Meta-analysis;
hemodialysis;
microinflammation;
nutritional status
- MeSH:
Capsules;
Cardiovascular Diseases/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Nutritional Status;
Renal Dialysis/adverse effects*
- From:
China Journal of Chinese Materia Medica
2022;47(9):2547-2555
- CountryChina
- Language:Chinese
-
Abstract:
This Meta-analysis was designed to evaluate the effects of Bailing Capsules on microinflammation and nutritional status of maintenance hemodialysis patients, and to determine its efficacy and safety. The randomized controlled trials concerning the intervention of microinflammation and nutritional status in maintenance hemodialysis patients with Bailing Capsules were searched from Chinese and English databases including CNKI, Wanfang, VIP, PubMed, EMbase, and Cochrane Library. A total of 16 articles were obtained, involving 1 095 cases. As revealed by Meta-analysis,(1)Bailing Capsules lowered the levels of serum high sensitivity C-reactive protein(SMD=-0.92, 95%CI[-1.05,-0.80], P<0.000 01), interleukin-6(SMD=-1.49, 95%CI[-1.96,-1.02], P<0.000 01), and tumor necrosis factor-α(SMD=-1.48, 95%CI[-1.68,-1.28], P<0.000 01) in patients with maintenance hemodialysis, thus alleviating microinflammation.(2)Bailing Capsules elevated the levels of serum hemoglobin(SMD=1.37, 95%CI[1.21, 1.54], P<0.000 01), albumin(SMD=0.78, 95%CI[0.57, 0.98], P<0.000 01), and triglyceride(SMD=0.29, 95%CI[0.07, 0.50], P=0.01) in patients with hemodialysis to improve their nutritional status.(3)Bailing Capsules reduced the incidence of cardiovascular events(RR=0.45, 95%CI[0.34, 0.59], P<0.000 01).(4)A total of six patients presented with mild gastrointestinal discomfort after receiving Bailing Capsules, and no serious adverse reactions were observed. The sequential analysis showed that the sample size of this Meta-analysis had reached the expected value. Meanwhile, the grade of evidence quality suggested that the outcome indicators were mainly low or extremely low in quality. In conclusion, Bailing Capsules might have potential advantages in alleviating microinflammation, improving nutritional status, and reducing the incidence of cardiovascular events. However, in view of the low quality and evidence of the included literature, high-quality clinical trials are needed to further confirm the efficacy and safety of Bailing Capsules.
