Discrimination of quality markers of Shujin Huoxue Capsules based on five principles coupled with cobweb model.
10.19540/j.cnki.cjcmm.20210525.304
- Author:
Ya ZHANG
1
;
Jian-Fei TANG
2
;
Qing-Hua TIAN
1
;
Ruo-Yu CHEN
1
;
Wei WANG
3
;
Wen-Xia WANG
3
;
Ji-Zhong YAN
1
;
Hui ZHANG
1
Author Information
1. College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou 310014, China.
2. Hangzhou Zhuyangxin Pharmaceutical Co., Ltd. Hangzhou 310011, China.
3. Hangzhou Huadong Medicine Group Kangrun Pharmaceutical Co., Ltd. Anji 313301, China.
- Publication Type:Journal Article
- Keywords:
Shujin Huoxue Capsules;
cobweb model;
five principles;
network pharmacology;
quality markers(Q-markers)
- MeSH:
Biomarkers;
Capsules;
Drugs, Chinese Herbal/pharmacology*
- From:
China Journal of Chinese Materia Medica
2022;47(9):2440-2448
- CountryChina
- Language:Chinese
-
Abstract:
The quality markers(Q-markers) of Shujin Huoxue Capsules were comprehensively discriminated based on the five principles of transfer and traceability, specificity, compatibility, effectiveness and measurability. The compounds that could be transferred from the original medicinal materials to the preparation were selected with the principle of transfer and traceability. The specific components in the prescription were screened by reviewing literature with the principle of specificity. According to the principle of compatibility, the attributes of compounds were evaluated by the sovereign, minister, assistant and guide combination rules of the original medicinal materials in the prescription. According to the principle of measurability, the measurable components were summarized by reference to the pharmacopoeia and literature combined with the content. The mechanism of Shujin Huoxue Capsules in the treatment of osteoporosis was studied through network pharmacology based on the principle of effectiveness, which was the evaluation index of effectiveness. The chemical components screened out above were regarded as candidate Q-markers, and the cobweb model was plotted to obtain the comprehensive score of Q-markers. Hydroxysafflor yellow A, trachelosid, eleutheroside B, α-cyperone, protocatechuic acid, protocatechualdehyde and 4-methoxy salicylaldehyde were discriminated as the Q-markers of Shujin Huoxue Capsules based on the five principles combined with cobweb model.
