Quality value transfer of material benchmark of Guizhi Jia Gegen Decoction.
10.19540/j.cnki.cjcmm.20211217.302
- Author:
Xin-Hao WAN
1
;
Wei-Feng ZHU
1
;
Li-Na YANG
1
;
Ling-Yun ZHONG
2
;
Mei XIA
2
;
Zhe LI
1
;
Li-Hua CHEN
1
;
Zhen-Zhong ZANG
1
;
Yong-Mei GUAN
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
2. School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Guizhi Jia Gegen Decoction;
classical prescription;
quality value transfer;
substance reference
- MeSH:
Ammonium Compounds;
Benchmarking;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Paeonia
- From:
China Journal of Chinese Materia Medica
2022;47(9):2430-2439
- CountryChina
- Language:Chinese
-
Abstract:
A total of 15 batches of the substance reference of Guizhi Jia Gegen Decoction(GZGGD) were prepared and the characteristic fingerprints of them were established. Furthermore, the similarity of the fingerprints and peak attributes were explored. The extraction rate, and the content and the transfer rate ranges of the index components, puerarin, paeoniflorin, liquiritin, and ammonium glycyrrhizate were determined for the analysis of the quality value transfer. The result demonstrated that the fingerprints of the 15 batches of the samples showed high similarity(>0.99). A total of 15 characteristic peaks were identified from the fingerprints, with 10 for Puerariae Lobatae Radix, 1 for Cinnamomi Ramulus, 2 for Paeoniae Radix Alba, and 2 for Glycyrrhizae Radix et Rhizoma. The content of puerarin was 11.05-18.35 mg·g~(-1) and the average transfer rate was 21.27%-39.49%. The corresponding figures were 7.95-10.90 mg·g~(-1) and 23.28%-43.23% for paeoniflorin, 3.25-4.95 mg·g~(-1) and 32.31%-61.27% for ammonium glycyrrhizate, and 3.65-5.80 mg·g~(-1) and 14.57%-27.05% for liquiritin. The extraction rate of the 15 batches of samples was in the range of 16.85%-21.78%. In this paper, the quality value transfer of the substance reference of GZGGD was analyzed based on characteristic fingerprint, content of index components, and the extraction rate. This study is expected to lay a basis for the quality control and further development of GZGGD.
