Hypoglycemic mechanism of Psoraleae Fructus and its main chemical constituents.
10.19540/j.cnki.cjcmm.20211229.701
- Author:
Ping-Ping LIN
1
;
Ming-Zhu CHEN
2
;
Yin ZHANG
3
Author Information
1. Department of Pharmacy, 2nd Affiliated Hospital of Fujian Medical University Quanzhou 362000, China College of Pharmacy, Fujian Medical University Fuzhou 350000, China.
2. College of Pharmacy, Quanzhou Medical College Quanzhou 362000, China.
3. Department of Pharmacy, 2nd Affiliated Hospital of Fujian Medical University Quanzhou 362000, China.
- Publication Type:Journal Article
- Keywords:
Psoraleae Fructus;
active ingredient;
diabetes mellitus;
hypoglycemia;
mechanism of action
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Fruit/chemistry*;
Humans;
Hypoglycemic Agents/pharmacology*;
Osteoporosis/drug therapy*;
Psoralea/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(9):2392-2399
- CountryChina
- Language:Chinese
-
Abstract:
With the rise of incidence, fatality rate, and number of young cases, diabetes mellitus has been one of the seven major diseases threatening human health. Although many antidiabetic drugs(oral or for injection) are available, the majority have serious side effects during the long-term use. Thus, it is of particularly vital to develop new drugs with low risk and definite effect. Psoraleae Fructus, a traditional medicinal widely used in the folk, has hypoglycemic, anti-osteoporosis, antitumor, estrogen-like, and anti-inflammatory effects. Thus, it has great clinical application potential. Chinese medicine and the active ingredients, characterized by multiple targets, multiple pathways, and multiple effects in the treatment of diabetes mellitus, have distinct advantages in clinical application. However, the safety of Chinese medicine remains to be a challenge, and one of keys is to clarifying the mechanism of a single Chinese medicinal and its active ingredients. With the method of literature research, this study summarized and analyzed the hypoglycemic mechanisms of Psoraleae Fructus and its main active ingredients over the last decade: regulating glucose metabolism, improving insulin resistance, and directly acting on pancreatic β-cells. The result is expected to serve as a reference for further research on the effects of Psoraleae Fructus and its main chemical constituents in lowering blood glucose and preventing diabetes mellitus and the clinical application.
