Development of Program for Renal Function Study with Quantification Analysis of Nuclear Medicine Image.
- Author:
Ju Young SONG
;
Hyoung Koo LEE
;
Tae Suk SUH
;
Bo Young CHOE
;
Kyung Sub SHIN
;
Yong An CHUNG
;
Sung Hoon KIM
;
Soo Kyo CHUNG
- Publication Type:Original Article
- Keywords:
99mTc-DTPA;
99mTc-MAG3;
Gamma camera;
Renal function;
Time activity curve;
Glomerular filtration rate;
Mean transit time.
- MeSH:
Adult;
Gamma Cameras;
Glomerular Filtration Rate;
Humans;
Kidney;
Microcomputers;
Nuclear Medicine*;
Radionuclide Imaging;
Running;
Technetium Tc 99m Mertiatide
- From:Korean Journal of Nuclear Medicine
2001;35(2):89-99
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this study, we developed a new software tool for the analysis of renal scintigraphy which can be modified more easily by a user who needs to study new clinical applications, and the appropriateness of the results from our program was studied. MATERIALS AND METHODS: The analysis tool was programmed with IDL5.2 and designed for use on a personal computer running Windows. For testing the developed tool and studying the appropriateness of the calculated glomerular filtration rate (GFR), 99mTc-DTPA was administered to 10 adults in normal condition. In order to study the appropriateness of the calculated mean transit time (MTT), 99mTc-DTPA and 99mTc-MAG3 were administered to 11 adults in normal condition and 22 kidneys were analyzed. All the images were acquired with ORBITOR, the Siemens gamma camera. RESULTS: With the developed tool, we could show dynamic renal images and time activity curve (TAC) in each ROI and calculate clinical parameters of renal function. The results calculated by the developed tool were not different statistically from the results obtained by the Siemens application program (Tmax: p=0.68, Relative Renal Function: p=1.0, GFR: p=0.25) and the developed program proved reasonable. The MTT calculation tool proved to be reasonable by the evaluation of the influence of hydration status on MTT. CONCLUSION: We have obtained reasonable clinical parameters for the evaluation of renal function with the software tool developed in this study. The developed tool could prove more practical than conventional, commercial programs.
