The inhibitory effect of platelet glycoprotein IIb/IIIa receptor blocker-coated stent on porcine coronary stent restenosis.
- Author:
Kyung Tae KANG
1
;
Myung Ho JEONG
;
Nam Ho KIM
;
Jay Young RHEW
;
Sang Hyun LEE
;
Jong Cheol PARK
;
Seung Uk LEE
;
Kun Hyung KIM
;
Myung Ja CHOI
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Woo Jin CHOI
;
Dong Lyun CHO
;
Jong Tae PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Restenosis;
Stents;
Platelet;
Glycoprotein IIb/IIIa Integrin;
Thrombus;
Neointima;
Proliferation
- MeSH:
Blood Platelets*;
Cell Proliferation;
Constriction, Pathologic;
Follow-Up Studies;
Glycoproteins*;
Humans;
Immunohistochemistry;
Myocytes, Smooth Muscle;
Neointima;
Plasma;
Polymerization;
Polymers;
Stents*;
Thrombosis;
Transplants
- From:Korean Journal of Medicine
2001;60(4):314-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The problems of coronary stent thrombosis and restenosis still remain to be solved.The glycoprotein IIb/IIIa receptor blocker, Abciximab (ReoPro), plays important roles in the treatment of high-risk patient with acute platelet-rich thrombus and in the inhibition of smooth muscle cell proliferation. The aim of this study was to determine whether the use of ReoPro-coated stents could reduce the neointimal formation in a porcine coronary stent restenosis model. METHODS: ReoPro was coated on the surface of stent by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13), and ReoPro-coated stents (Group II, n=14). Follow-up quantitative coronary angiogram was performed at 4 weeks after stenting and histopathologic assessment were compared in both groups. RESULTS: The diameter stenosis by QCA between two groups was significantly higher in Group I (23+/-5 % vs. 15+/-7 %, p=0.003). On histopathologic examination, no in-stent thrombus was observed. The percent area stenosis was significantly higher in Group I than in Group II (48+/-17 % vs. 30+/-16 %, p=0.01). The area of neoinima was larger in Group I than in Group II (3.2+/-1.2 mm2 vs. 2.0+/-1.0 mm2, p=0.01). By immunocytochemistry, proliferation cell nuclear antigen indices were higher in Group I (4.2+/-2.1 %, vs 2.4+/-1.8 % p=0.03). CONCLUSION: The ReoPro-coated stent is safe and effective in the prevention of in-stent thrombus and restenosis, which may be related with the inhibition of platelet thrombus and neointimal cell proliferation.
