Effects of Qilong Capsules on myocardial fibrosis and insufficient blood circulation in ischemic cardiomyopathy with Qi deficiency and blood stasis.
10.19540/j.cnki.cjcmm.20211216.701
- Author:
Jia-Ming GAO
1
;
Hao GUO
1
;
Ye-Hao ZHANG
1
;
Ming-Jiang YAO
1
;
Jing WEN
1
;
Yue YOU
1
;
Jian-Hua FU
1
;
Jian-Xun LIU
1
Author Information
1. Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, National Clinical Research Center of Cardiovascular Disease of Traditional Chinese Medicine, Institute of Basic Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
- Publication Type:Journal Article
- Keywords:
Qi deficiency and blood stasis syndrome;
Qilong Capsules;
blood circulation;
ischemic cardiomyopathy;
myocardial fibrosis
- MeSH:
Animals;
Capsules;
Cardiomyopathies/drug therapy*;
Fibrosis;
Myocytes, Cardiac;
Qi;
Rats;
Rats, Sprague-Dawley;
Stroke Volume;
Ventricular Function, Left
- From:
China Journal of Chinese Materia Medica
2022;47(5):1327-1335
- CountryChina
- Language:Chinese
-
Abstract:
Protective effect of Qilong Capsules(QL) on the myocardial fibrosis and blood circulation of rats with coronary heart disease of Qi deficiency and blood stasis type was investigated. Sleep deprivation and coronary artery ligation were used to construct a disease-symptom combination model, and 60 SD rats were divided into sham operation(sham) group, syndrome(S) group, disease and syndrome(M) group and QL group randomly. The treatment group received administration of QL 0.4 g·kg~(-1)·d~(-1). Other groups were given the same amount of normal saline. The disease indexes of each group [left ventricular end diastolic diameter(LVESD), left ventricular end systolic diameter(LVEDD), left ventricular ejection fraction(LVEF), left ventricular axis shortening rate(LVFS), myocardial histopathology, platelet morphology, peripheral blood flow] and syndrome indexes(tongue color, pulse, grip power) were detected. In sham group, cardiomyocytes and myocardial fibers were arranged neatly and densely with clear structures. The tongues' color in sham were light red, and the pulse shape were regular. RGB is a parameter reflected the brightness of the image of the tongue. In the S group, the amplitude and frequency of the animal's pulse increased accompanied by decreasing R,G,B, however, the decreased R,G,B was accompanied by reduced pulse amplitude in M group. And in M group, we observed fuzzy cell morphology, hypertrophied myocytes, disordered arrangement of cardiomyocytes and myocardial fibers, reduced peripheral blood flow and increased collagen volume fraction(CVF). Increased LVESD and LVEDD, and decreased LVEF and LVFS represented cardiac function in S group was significantly lower than that in sham. In QL group, the tongue's color was red and the pulse was smooth. The myocardial fibers of the QL group were arranged neatly and secreted less collagen. It improved the blood circulation in the sole and tail, and reversed the increasing of LVEDD, LVESD and the decreasing of LVEF and LVFS of M group. Platelets in M and S group showed high reactivity, and QL could decrease aggregation risk. In conclusion, Qilong Capsules has an obvious myocardial protective effect on ischemic cardiomyopathy, which may inhibit the degree of myocardial fibrosis and reduce platelet reactivity.
