Preparation and in vitro release of quercetin nanocrystals self-stabilized Pickering emulsion.
10.19540/j.cnki.cjcmm.20210525.301
- Author:
Zhe WANG
1
;
Fei HU
2
;
Zhi-Hui CHE
2
;
Qing SONG
2
;
Bao-de SHEN
2
;
Hai-Long YUAN
2
Author Information
1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
2. Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
- Publication Type:Journal Article
- Keywords:
Pickering emulsion;
high-pressure homogenization;
nanocrystals;
probe ultrasonic method;
quercetin;
self-stabilized
- MeSH:
Emulsions/chemistry*;
Nanoparticles;
Particle Size;
Quercetin;
Water/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(5):1230-1236
- CountryChina
- Language:Chinese
-
Abstract:
A new quercetin nanocrystals self-stabilized Pickering emulsion(QT-NSSPE) was prepared by high-pressure homogenization combined with probe ultrasonic method. The influences of oil fraction, quercetin(QT) concentration, and pH of water phase on the formation of QT-NSSPE were investigated. On this basis, the QT-NSSPE prepared under optimal conditions was evaluated in terms of microstructure, stability, and in vitro release and the droplet size and drug loading were 15.82 μm and 4.87 mg·mL~(-1), respectively. The shell structure formed by quercetin nanocrystals(QT-NC) on the emulsion droplet surface was observed under a scanning electron microscope(SEM). X-ray diffraction(XRD) showed that the crystallinity of adsorbed QT-NC decreased significantly as compared with the raw QT. There were not significant changes of QT-NSSPE properties after 30 days of storage at room temperature. The in vitro release experiment confirmed that QT-NSSPE has a higher accumulative release rate than the raw QT. All these results indicated that QT-NSSPE has a great stability and a satisfactory in vitro release behavior, which is a promising new oral delivery system for QT.
