Twenty years in the 21st century: research approaches and techniques in modern system biology for mechanisms of Chinese medicinal processing.
10.19540/j.cnki.cjcmm.20211216.601
- Author:
Shu-Chen GUO
1
;
De-Tian LI
1
;
Shi-Kui LIANG
1
;
Wei WU
1
;
Bing YANG
1
;
Liang FENG
1
;
Xiao-Bin JIA
1
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
efficacy enhancing and toxicity reducing;
mechanism of Chinese medicinal processing;
muti-omics;
system biology
- MeSH:
China;
Genomics;
Medicine, Chinese Traditional;
Metabolomics/methods*;
Proteomics
- From:
China Journal of Chinese Materia Medica
2022;47(5):1170-1176
- CountryChina
- Language:Chinese
-
Abstract:
Clarifying the mechanisms of Chinese medicinal processing is pivotal to the modernization of Chinese medicine. Research on Chinese medicinal processing gives priority to the mechanisms of the processing in enhancing efficacy, reducing toxicity, and repurposing medicinals. During the past 20 years, scholars have carried out in-depth studies on the mechanisms of Chinese medicinal processing via modern system biology. They mainly focused on the changes of medicinal properties and efficacy caused by processing using techniques of modern pharmacology and molecular biology, spectrum-efficacy correlation, and biophoton emission. However, these techniques fail to reflect the holistic view of traditional Chinese medicine. With the introduction of system biology, multi-omics techno-logies(genomics, transcriptomics, proteomics, and metabolomics) have surged, which have been applied to the research on the mec-hanisms of Chinese medicinal processing. These multi-omics technologies have advantages in the research on holism. This study aims to summarize the research techniques and approaches in system biology for mechanisms of Chinese medicinal processing in the past 20 years and analyze the limitations and advantages of them. It is concluded that the multi-omics techniques of system biology can reconstruct the mechanisms of Chinese medicinal processing. This study provides a new direction for further research on the mechanisms of Chinese medicinal processing.
