A new polyketide of endophytic fungi Aspergillus sp. ZJ-58 from Coptis chinensis.
10.19540/j.cnki.cjcmm.20211102.203
- Author:
Guo-Ping YIN
1
;
Chun WEN
1
;
Ya-Juan LI
1
;
Du SHI
2
;
Jing-Jing ZHU
3
;
Chang-Hua HU
1
Author Information
1. Engineering Research Center for Development and Utilization of Coptis Chinensis, College of Pharmaceutical Sciences, Southwest University Chongqing 400716, China.
2. Jiulongpo District Hospital of Traditional Chinese Medicine Chongqing 400050, China.
3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Coptis chinensis;
anti-inflammatory activity;
coptaspin A;
endophytic fungi
- MeSH:
Anti-Inflammatory Agents/pharmacology*;
Aspergillus/chemistry*;
Coptis chinensis;
Plants, Medicinal;
Polyketides/pharmacology*
- From:
China Journal of Chinese Materia Medica
2022;47(4):967-971
- CountryChina
- Language:Chinese
-
Abstract:
A new polyketide, coptaspin A(1), along with two known compounds 4-acetyl-3,4-dihydro-6,8-dihydroxy-3-methoxy-5-methylisocoumarin(2), and cytochalasin Z_(12)(3), was isolated from the endophytic fungi Aspergillus sp. ZJ-58, which was isolated from the genuine medicinal plant Coptis chinensis in Chongqing after solid-state fermentation on rice and silica gel, MCI, and HPLC-based separation. Their structures were elucidated by MS, NMR, IR, UV, and ECD. The newly isolated compound 1 showed moderate inhibitory activities against LPS-induced NO production in RAW264.7 macrophages with the IC_(50) value of 58.7 μmol·L~(-1), suggesting its potential anti-inflammatory activity.
