Diterpenoids from Rabdosia flexicaulis.
10.19540/j.cnki.cjcmm.20210907.201
- Author:
Xu LIU
1
;
Chun-Xia CHEN
2
;
Ji-Zhou WU
3
Author Information
1. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China.
2. Wuhan Vocational College of Software and Engineering Wuhan 430050, China School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China.
3. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China.
- Publication Type:Journal Article
- Keywords:
Rabdosia flexicaulis;
abietane;
diterpenoid;
ent-kaurane
- MeSH:
Diterpenes;
Diterpenes, Kaurane;
Isodon/chemistry*;
Molecular Structure;
Plant Extracts/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(2):433-436
- CountryChina
- Language:Chinese
-
Abstract:
The genus Rabdosia is famous for the abundance of diverse and novel ent-kaurane diterpenoids. However, only a few ent-kauranoids have been discovered from R. flexicaulis since the investigation on its chemical constituents is not systematic. To find novel bioactive diterpenoids, the ethyl acetate extract of the above ground part of R. flexicaulis in Daofu County, Sichuan Province was obtained by column chromatography. One new compound and five known ones were identified as flexicaulin E(1), forrestin B(2), inf-lexarabdonin D(3), 7α-hydroxydehydroabietic acid(4), 15-hydroxydehydroabietic acid(5), and pomiferin F(6) by spectral techniques. Compounds 1-3 were the ent-kaurane diterpenoids isolated from this species for the first time. Compounds 4-6, aromatic abie-tanoids, were isolated from the genus Rabdosia for the first time.
