New eudesmane sesquiterpenoids from Atractylodis Macrocephalae Rhizoma and their inhibitory activities against SREBPs.
10.19540/j.cnki.cjcmm.20211014.201
- Author:
Rui-Zhu XU
1
;
Xuan ZHAO
2
;
Yue-Yue DU
1
;
Meng-Sha XU
2
;
Xin-Guang LIU
3
;
Zhi-Shen XIE
3
;
Song GAO
4
;
Jiang-Yan XU
3
;
Pan WANG
5
Author Information
1. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine Zhengzhou 450046, China School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China.
2. School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China.
3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine Zhengzhou 450046, China.
4. Henan Province Technological Innovation Center for Solid Preparation of Traditional Chinese Medicine, Zhongjing Wanxi Pharmaceutical Co., Ltd. Nanyang 474500, China.
5. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine Zhengzhou 450046, China Henan Province Technological Innovation Center for Solid Preparation of Traditional Chinese Medicine, Zhongjing Wanxi Pharmaceutical Co., Ltd. Nanyang 474500, China.
- Publication Type:Journal Article
- Keywords:
Atractylodis Macrocephalae Rhizoma;
SREBPs inhibitor;
chemical constituent;
sesquiterpenoid
- MeSH:
Atractylodes/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Rhizome/chemistry*;
Sesquiterpenes, Eudesmane/pharmacology*;
Sterol Regulatory Element Binding Proteins/antagonists & inhibitors*
- From:
China Journal of Chinese Materia Medica
2022;47(2):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Three sesquiterpenoids were isolated and purified from the 95% ethanol extract of Atractylodis Macrocephalae Rhizoma by column chromatography on silica gel, Sephadex LH-20, ODS, and high-performance liquid chromatography(HPLC). Their chemical structures were identified on the basis of spectroscopic analysis and physiochemical properties as(7Z)-8β,13-diacetoxy-eudesma-4(15),7(11)-diene(1), 7-oxo-7,8-secoeudesma-4(15),11-dien-8-oic acid(2), and guai-10(14)-en-11-ol(3). Compounds 1 and 2 are new compounds and compound 3 was obtained from Compositae family for the first time. Compounds 1, 2, and 3 showed weak inhibitory activities against sterol regulatory element-binding proteins(SREBPs).
