Mechanism of Syringa oblata in treating angina pectoris based on GC-MS and network pharmacology.
10.19540/j.cnki.cjcmm.20210927.201
- Author:
Zhu-la GEGEN
1
;
Ya GAO
2
;
Ge-le SITE
1
;
Chaolu-Men ALATAN
1
;
Bada-Lahu TAI
3
;
Ya TU
2
Author Information
1. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities Tongliao 028000, China.
2. Development Research Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
3. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities Tongliao 028000, China Mongolian Medicine Research Center, Inner Mongolia University for Nationalities Tongliao 028000, China.
- Publication Type:Journal Article
- Keywords:
GC-MS;
angina pectoris;
network pharmacology;
volatile oil of Syringa oblata
- MeSH:
Angina Pectoris;
Drugs, Chinese Herbal/pharmacology*;
Gas Chromatography-Mass Spectrometry;
Humans;
Molecular Docking Simulation;
Network Pharmacology;
Syringa
- From:
China Journal of Chinese Materia Medica
2022;47(3):836-845
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents in the volatile oil of Syringa oblata were identified using GC-MS and NIST database. TCMSP and SwissTargetPrediction were employed to predict the potential targets of the active components in S. oblata. Through Online Mendelian Inheritance in Man(OMIM), GeneCards, and Kyoto Encyclopedia of Genes and Genomes(KEGG), we screened out the targets related to the prevention or treatment of angina pectoris by the volatile oil of S. oblata, and then used DAVID 6.8 to annotate the gene ontology(GO) terms and KEGG pathways. The "active components-targets-pathways" network was constructed in Cytoscape 3.6.0, and the key active components and targets of S. oblata were verified by Discovery Studio 2016. Forty-six chemical constituents were identified from the volatile oil of S. oblata; 198 potential targets of the active components and 1 138 targets associated with angina pectoris were predicted. A total of 71 common targets were shared by the active components and the disease, including cytochrome P450 19 A1(CYP19 A1) and prostaglandin G/H synthase 2(PTGS2). The KEGG pathways involved include PPAR, JAK-STAT, TNF, Toll-like receptor and NOD-like receptor signaling pathways. The active components in the volatile oil of S. oblata may play anti-inflammatory and anti-apoptosis roles. This study provides a reliable clue for further explanation of the effective components and the functioning mechanism of S. oblata in the treatment of angina pectoris.
