Metabonomics and its application in Chinese medicine processing.
10.19540/j.cnki.cjcmm.20210927.601
- Author:
Xin-Tong WEI
1
;
Jie WANG
2
;
Wei CHEN
3
;
Yan-Ping WEI
2
;
Yan-Hui LYU
2
;
Xian-Peng ZU
3
;
Xiu-Yun ZHANG
2
Author Information
1. School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China School of Pharmacy, Naval Medical University Shanghai 200433, China.
2. School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
3. School of Pharmacy, Naval Medical University Shanghai 200433, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine processing;
metabonomics;
processing mechanism;
quality control
- MeSH:
Chromatography, Liquid;
Drugs, Chinese Herbal;
Mass Spectrometry;
Medicine, Chinese Traditional;
Metabolomics/methods*;
Quality Control
- From:
China Journal of Chinese Materia Medica
2022;47(3):593-602
- CountryChina
- Language:Chinese
-
Abstract:
Chinese medicine processing is a procedure to process medicinal materials under the guidance of traditional Chinese medicine(TCM) theories by using unique methods in China. The medicinal materials can only be used clinically after proper processing. With the development of the modernization of TCM, it is difficult to solve the problems in the inheritance, development, and internationalization of Chinese medicine processing. Metabonomics, a new omics technology developed at the end of the last century, is used to infer the physiological or pathological conditions of the organism with the methods such as NMR and LC-MS via investigating the changes in endogenous small molecule metabolic network after the organism is stimulated by external environment. Metabonomics coincides with the holistic view of TCM because it displays the characteristics of integrity, comprehensiveness, and dynamics, and it has been widely applied in the field of Chinese medicine processing in recent years. This study summarized the application of metabonomics in the processing mechanism and quality control of Chinese medicine processing and prospected the development of this technology in the field of Chinese medicine processing.
