Meta-analysis of efficacy and safety of Liuwei Wuling Tablets combined with conventional drugs in treatment of liver fibrosis and cirrhosis in chronic hepatitis B.
10.19540/j.cnki.cjcmm.20210728.501
- Author:
Man-Ting HOU
1
;
Kai-Xin DING
2
;
Ting-Ting HE
3
;
Yan YANG
4
;
Zhao-Fang BAI
2
;
Xiao-He XIAO
5
Author Information
1. School of Chinese Medicine, Southern Medical University Guangzhou 510515, China Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
2. Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
3. Department of Integrated Chinese and Western Medicine, the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
4. School of Chinese-Western Medicine Integration, Southwest Medical University Luzhou 646000, China Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
5. Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China School of Chinese Medicine, Southern Medical University Guangzhou 510515, China.
- Publication Type:Meta-Analysis
- Keywords:
Liuwei Wuling Tablets;
Meta-analysis;
chronic hepatitis B;
efficacy;
liver cirrhosis;
liver fibrosis;
safety
- MeSH:
Drugs, Chinese Herbal/adverse effects*;
Hepatitis B, Chronic/drug therapy*;
Humans;
Liver Cirrhosis/drug therapy*;
Tablets
- From:
China Journal of Chinese Materia Medica
2022;47(1):224-234
- CountryChina
- Language:Chinese
-
Abstract:
The present study evaluated the clinical efficacy and safety of Liuwei Wuling Tablets combined with conventional drugs for the treatment of liver fibrosis and cirrhosis in chronic hepatitis B. CNKI, Wanfang, VIP, CBM, PubMed, EMbase and Cochrane Library were searched for the relevant randomized controlled trials(RCTs) published from database inception to February 2021. All the retrieved papers were independently screened, extracted and evaluated by two researchers, followed by Meta-analysis by Review Manager 5.4. Finally, 18 RCTs were included, involving 2 168 patients(1 106 in the treatment group and 1 062 in the control group). The Meta-analysis results showed that compared with conventional drugs alone, Liuwei Wuling Tablets combined with conventional drugs could increase the effective rate of clinical treatment by reducing serum hyaluronic acid(HA), laminin(LN), procollagen type Ⅲ(PCⅢ), and type Ⅳ collagen(Ⅳ-C) to improve liver function, decreasing the levels of total bilirubin(TBiL), alanine amino-transferase(ALT), and aspartate aminotransferase(AST), and improving the negative conversion ratio of hepatitis B virus(HBV) DNA. In terms of safety, there were no serious adverse reactions in the treatment group and the control group. The results showed that Liuwei Wuling Tablets combined with antiviral or other conventional liver-protecting drugs could improve liver function, treat liver cirrhosis, and reduce liver fibrosis with high safety. However, due to the influence of literature quality and quantity, multi-center and high-quality RCTs with large sample size are needed for verification.
