Chemical constituents of cyclic peptides from fibrous roots of Pseudostellaria heterophylla.
10.19540/j.cnki.cjcmm.20210816.201
- Author:
Qian-Feng CHEN
1
;
Xiao-Fei ZHAO
2
;
Han-Tao ZHAO
2
;
Lyu-Jiang YUAN
1
Author Information
1. College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China the MOE Engineering Research Center of Coptis Development & Utilization, Southwest University Chongqing 400715, China.
2. College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.
- Publication Type:Journal Article
- Keywords:
chemical constituent;
cyclic peptide;
fibrous roots of Pseudostellaria heterophylla
- MeSH:
Caryophyllaceae/chemistry*;
Chromatography, High Pressure Liquid;
Magnetic Resonance Spectroscopy;
Peptides, Cyclic/pharmacology*;
Plant Roots/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(1):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Four cyclic peptides were isolated from the 75% ethanol extract of the fibrous roots of Pseudostellaria heterophylla by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. Through mass spectrometry, NMR and other methods, they were identified as pseudostellarin L(1), heterophyllin B(2), pseudostellarin B(3), and pseudostellarin C(4). Among them, compound 1 was a new cyclic peptide, and compounds 2-4 were isolated from the fibrous roots of P. heterophylla for the first time. None of these compounds displayed cytotoxic activities against MCF-7, A549, HCT-116, and SGC-7901 cells.
