Co-amorphous technology to improve dissolution and physical stability of silybin.
10.19540/j.cnki.cjcmm.20210511.301
- Author:
Huan LIU
1
;
Guo-Wei ZHAO
1
;
Qie-Ying JIANG
2
;
Xin-Li LIANG
1
;
Liao-Qi OUYANG
1
;
Hai-Bo DING
1
;
Xu-Long CHEN
1
;
Zheng-Gen LIAO
1
Author Information
1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.
2. Laboratory Animal Science and Technology Center, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
co-amorphous;
dissolution;
puerarin;
silybin;
stability
- MeSH:
Calorimetry, Differential Scanning;
Desiccation;
Drug Compounding/methods*;
Drug Stability;
Silybin;
Solubility;
Spectroscopy, Fourier Transform Infrared;
Technology;
X-Ray Diffraction
- From:
China Journal of Chinese Materia Medica
2022;47(1):103-110
- CountryChina
- Language:Chinese
-
Abstract:
The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method. Solid-state characterization was carried out by powder X-ray diffraction(PXRD), polarizing microscopy(PLM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC), etc. Saturated powder dissolution, intrinsic dissolution rate, moisture absorption, and stability were further investigated. The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug. The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system. The co-amorphous system kept stable for as long as three months under the condition of 40 ℃, 75% relative humidity, which was longer than that of the single amorphous silybin. Therefore, the co-amorphous technology could significantly improve the dissolution and stability of silybin.
