Traditional Chinese medicine network pharmacology: development in new era under guidance of network pharmacology evaluation method guidance.
10.19540/j.cnki.cjcmm.20210914.702
- Author:
Zi-Yi WANG
1
;
Xin WANG
1
;
Dai-Yan ZHANG
2
;
Yuan-Jia HU
2
;
Shao LI
1
Author Information
1. Ministry of Education Key Laboratory of Bioinformatics/Bioinformatics Division, Beijing National Research Center for Information Science and Technology, Department of Automation, Institute of Traditional Chinese Medicine-X, Tsinghua University Beijing 100084, China.
2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078, China.
- Publication Type:Review
- Keywords:
Network Pharmacology Evaluation Method Guidance;
network pharmacology;
network target;
traditional Chinese medicine
- MeSH:
Artificial Intelligence;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Network Pharmacology;
Research Design
- From:
China Journal of Chinese Materia Medica
2022;47(1):7-17
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) has unique advantages in the prevention and treatment of diseases owing to its holistic view and more than 2 000 years of experience in the clinical use of natural medicine. The "holistic" characteristic of TCM gives birth to a new generation of research paradigm featuring "network" and "system", which has been developing rapidly in the era of biomedical big data and artificial intelligence. Network pharmacology, a representative research field, provides new ideas and methods for the research of the interdiscipline of artificial intelligence and medicine, the analysis of massive biomedical data, and the transformation from data to knowledge. TCM plays an important role in proposing the core theory of "network target" and promoting the establishment and development of network pharmacology, and has taken the lead in formulating the first international standard of network pharmacology--Network Pharmacology Evaluation Method Guidance. In terms of theory, network target can systematically link drugs and diseases and quantitatively interpret the overall regulatory mechanism of drugs. In the aspect of method, network pharmacology is developing towards a research model that combines computational, experimental, and clinical approaches. This review introduces the resent important progress of TCM network pharmacology in predicting drug targets, understanding the biological basis of drugs and diseases, and searching for disease and syndrome biomarkers. Under the guidance of Network Pharmacology Evaluation Method Guidance, the development of network pharmacology is expected to become more and more standardized and healthy. Network target will help produce more high-quality research outcomes in TCM and effectively boost the modernization and internationalization of TCM.
