Metabolomics in Diabetic Neuropathy.
10.3881/j.issn.1000-503X.13040
- Author:
Qian ZHANG
1
;
Wei SONG
2
;
Xiao-Chun LIANG
1
Author Information
1. Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Medical Research Center,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
diabetes;
diabetic neuropathy;
metabolomics
- MeSH:
Biomarkers;
Diabetes Mellitus;
Diabetic Neuropathies;
Humans;
Hyperglycemia/complications*;
Metabolomics
- From:
Acta Academiae Medicinae Sinicae
2022;44(2):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic neuropathy is a common diabetic complication.The application of metabolomics in the research on diabetic neuropathy is beneficial for us to understand the pathophysiological processes and overall metabolic disturbance of the nervous system under the condition of hyperglycemia,decipher the pathogenesis of diabetic neuropathy,and mine the potential biomarkers for clinical diagnosis and treatment.Long-term hyperglycemia may lead to disorders in multiple pathways,such as tricarboxylic acid circle,amino acid metabolism,and lipid metabolism.These metabolic changes are closely associated with the injuries of the peripheral and central nervous system.In the paper,we reviewed the metabolomics-based studies about diabetic neuropathy in the last five years.
