Immunotherapy Based on Tumor Microenvironment in Renal Cell Carcinoma.
10.3881/j.issn.1000-503X.13013
- Author:
Song-Chen HAN
;
Hua-Qi YIN
;
Tao XU
- Publication Type:Journal Article
- Keywords:
biomarker;
carcinoma-associated fibroblasts;
immunotherapy;
renal cell carcinoma;
tumor microenvironment
- MeSH:
Carcinoma, Renal Cell/therapy*;
Female;
Humans;
Immune Checkpoint Inhibitors;
Immunotherapy;
Kidney Neoplasms/therapy*;
Male;
Tumor Microenvironment
- From:
Acta Academiae Medicinae Sinicae
2022;44(2):305-312
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma (RCC) is a common lethal urological cancer,the distant metastasis of which is the leading cause of death.Although targeted agents have remarkably improved the overall prognosis of RCC patients,nearly all the patients eventually acquire therapeutic resistance.With the advent of immune checkpoint inhibitors,immunotherapy based on tumor microenvironment (TME) has shown a broad scope in clinical application.The deepening understanding of TME leads to the changes of therapeutic strategies for advanced RCC,and the combination of targeted therapy and immunotherapy is exhibiting a promising prospect.Herein,we reviewed the TME characteristics,candidate predictive biomarkers,and possible targets for future development of drugs against RCC.
